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TLQP-62 (mouse,rat)
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Catalog No. TP3948
TLQP-62 (mouse, rat) is a secreted C-terminal peptide derived from the protein VGF. It activates the BDNF-TrkB signaling pathway, inducing acute and transient phosphorylation of TrkB receptors and downstream phosphorylation of CREB(Ser133). TLQP-62 effectively enhances long-term fear memory formation in wild-type mice and can reverse memory deficits in VGF heterozygous knockout mice. This compound is useful for researching memory-related neurological diseases, such as Alzheimer's disease and frontotemporal dementia.
TLQP-62 (mouse,rat)
TLQP-62 (mouse,rat)
😃Good
Catalog No. TP3948
TLQP-62 (mouse, rat) is a secreted C-terminal peptide derived from the protein VGF. It activates the BDNF-TrkB signaling pathway, inducing acute and transient phosphorylation of TrkB receptors and downstream phosphorylation of CREB(Ser133). TLQP-62 effectively enhances long-term fear memory formation in wild-type mice and can reverse memory deficits in VGF heterozygous knockout mice. This compound is useful for researching memory-related neurological diseases, such as Alzheimer's disease and frontotemporal dementia.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | TLQP-62 (mouse, rat) is a secreted C-terminal peptide derived from the protein VGF. It activates the BDNF-TrkB signaling pathway, inducing acute and transient phosphorylation of TrkB receptors and downstream phosphorylation of CREB(Ser133). TLQP-62 effectively enhances long-term fear memory formation in wild-type mice and can reverse memory deficits in VGF heterozygous knockout mice. This compound is useful for researching memory-related neurological diseases, such as Alzheimer's disease and frontotemporal dementia. |
| In vitro | TLQP-62 (10 μM, 10 min) rapidly and transiently activates TrkB receptor phosphorylation. At a concentration of 10 μM for 30 minutes, TLQP-62 induces CREB phosphorylation at Ser133 and enhances cofilin phosphorylation in mouse hippocampal slices. |
| In vivo | TLQP-62, when administered bilaterally into the hippocampus at a dose of 0.3 μg/side immediately after training, enhances long-term fear memory formation in mice. Additionally, a single intraperitoneal injection of TLQP-62 at 5 mg/kg, given right after training, reverses memory deficits in male N2F1 VGF heterozygous knockout mice. |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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