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5,6-Dihydrouridine

Name: 5,6-Dihydrouridine
Brand: TargetMol
SKU: T19146
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19146Cas No. 5627-05-4

5,6-Dihydrouridine, a modified base, is located in conserved positions within the D-loop of tRNA in Eukaryota, Bacteria, and some Archaea.

5,6-Dihydrouridine

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Purity: 99.27%

Catalog No. T19146Cas No. 5627-05-4

5,6-Dihydrouridine, a modified base, is located in conserved positions within the D-loop of tRNA in Eukaryota, Bacteria, and some Archaea.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
5 mg	$81	-	In Stock
10 mg	$123	-	In Stock
25 mg	$197	-	In Stock
1 mL x 10 mM (in DMSO)	$89	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.27%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	5,6-Dihydrouridine, a modified base, is located in conserved positions within the D-loop of tRNA in Eukaryota, Bacteria, and some Archaea.
Targets&IC50	Cytidine deaminase (E. coli):3.4 μM(Ki)
In vitro	5,6-Dihydrouridine (Dihydrouridine) is a posttranscriptionally modified nucleoside, resulting from the reduction of uridine (U) and can be further altered to 5-methyldihydrouridine (m5D). It is identified in six positions within the 'D-loop' of tRNA (16, 17, 20a, 20b) and in position 47 of the variable loop.

Chemical Properties

Molecular Weight	246.22
Formula	C₉H₁₄N₂O₆
Cas No.	5627-05-4
Smiles	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1CCC(=O)NC1=O
Relative Density.	1.614g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 90 mg/mL (365.53 mM), Sonication is recommended.

DMSO: 32.1 mg/mL (130.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	4.0614 mL	20.3070 mL	40.6141 mL	203.0704 mL
5 mM	0.8123 mL	4.0614 mL	8.1228 mL	40.6141 mL
10 mM	0.4061 mL	2.0307 mL	4.0614 mL	20.3070 mL
20 mM	0.2031 mL	1.0154 mL	2.0307 mL	10.1535 mL
50 mM	0.0812 mL	0.4061 mL	0.8123 mL	4.0614 mL
100 mM	0.0406 mL	0.2031 mL	0.4061 mL	2.0307 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc