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Ecopipam

Name: Ecopipam
Brand: TargetMol
SKU: T31602
Price: 266 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31602Cas No. 112108-01-7

Alias UNII-0X748O646K, Sch-39166, Sch 39166

Ecopipam (UNII-0X748O646K) is a potent, selective, and orally active antagonist of dopamine D1/D5 receptors, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam demonstrates more than 40-fold selectivity over D2, D4, 5-HT, and α2a receptors (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). It is used in research on schizophrenia and obesity.

Ecopipam

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Purity: 99.68%

Catalog No. T31602Alias UNII-0X748O646K, Sch-39166, Sch 39166Cas No. 112108-01-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$266	In Stock	In Stock
5 mg	$745	In Stock	In Stock
10 mg	$1,190	In Stock	In Stock
25 mg	$2,085	In Stock	In Stock
50 mg	$3,335	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.68%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ecopipam (UNII-0X748O646K) is a potent, selective, and orally active antagonist of dopamine D1/D5 receptors, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam demonstrates more than 40-fold selectivity over D2, D4, 5-HT, and α2a receptors (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). It is used in research on schizophrenia and obesity.
Targets&IC50	α2A-adrenoceptor:731 nM (Ki), 5-HT receptor:80 nM (Ki), D5 receptor:2.0 nM (Ki), D1 receptor:1.2 nM (Ki), D4 Receptor:5520 nM (Ki), D2 Receptor:980 nM (Ki)
In vitro	Ecopipam (2 μM) completely abolishes the proconvulsive effect of Dopamine (10 μM) in isolated corticohippocampal formation[2].
In vivo	Ecopipam (0.003-0.3 mg/kg; a single s.c.) abolishes nicotine-induced enhancement of a sensory reinforcer in adult rats[3]. Ecopipam (10 mg/kg, oral administration) antagonizes apomorphine-induced stereotypy in rats[4]. Ecopipam (5 and 10 μM, perfusion, 1 μL/min) reversibly and dose-dependently decreases acetylcholine release in the rat striatum[5].
Synonyms	UNII-0X748O646K, Sch-39166, Sch 39166

Chemical Properties

Molecular Weight	313.82
Formula	C₁₉H₂₀ClNO
Cas No.	112108-01-7
Smiles	CN1[C@@]2([C@@](C=3C(=CC(Cl)=C(O)C3)CC1)(C=4C(CC2)=CC=CC4)[H])[H]
Relative Density.	1.220 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (191.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (7.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1865 mL	15.9327 mL	31.8654 mL	159.3270 mL
5 mM	0.6373 mL	3.1865 mL	6.3731 mL	31.8654 mL
10 mM	0.3187 mL	1.5933 mL	3.1865 mL	15.9327 mL
20 mM	0.1593 mL	0.7966 mL	1.5933 mL	7.9664 mL
50 mM	0.0637 mL	0.3187 mL	0.6373 mL	3.1865 mL
100 mM	0.0319 mL	0.1593 mL	0.3187 mL	1.5933 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc