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BMS 182874 hydrochloride
🥰Excellent
Catalog No. T21790Cas No. 1215703-04-0
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
BMS 182874 hydrochloride
🥰Excellent
Purity: 97.01%
Catalog No. T21790Cas No. 1215703-04-0
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $74 | In Stock | |
| 2 mg | $98 | In Stock | |
| 5 mg | $151 | In Stock | |
| 10 mg | $227 | In Stock | |
| 25 mg | $381 | In Stock | |
| 50 mg | $531 | In Stock | |
| 100 mg | $738 | In Stock | |
| 200 mg | $996 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $157 | In Stock |
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Purity:97.01%
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Product Introduction
Bioactivity
Chemical Properties
| Description | BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist. |
| In vitro | BMS-l 82874 inhibited ET-l -stimulated inositol phosphate accumulation (KB 75 nM) and calcium mobilization (Ki = 140 nM) without suppressing the maximal responses in VSM-A10 cells. BMS-182874 competitively inhibited the binding of [125I]ET-1 to ETA receptors in rat vascular smooth muscle A10 (VSM-A10) cell membranes (Ki = 61 nM) and in CHO cells stably expressing the human ETA receptor (Ki = 48 nM), but was a weak inhibitor at ETB receptors (Ki > 50 μM) and non-ET receptors. |
| In vivo | BMS-182874 blunted the pressor response to exogenous ET-l when administered either orally (ED50 = 30 μmol/kg) or intravenously (ED50 = 24 μmol/kg) to conscious, normotensive rats. |
| Molecular Weight | 381.88 |
| Formula | C17H20ClN3O3S |
| Cas No. | 1215703-04-0 |
| Smiles | CC1=C(NS(=O)(C2=CC=CC3=C2C=CC=C3N(C)C)=O)ON=C1C.Cl |
| Relative Density. | no data available |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (130.93 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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