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Brittonin A (Synonyms: 1,2-Bis(3,4,5-trimethoxyphenyl)ethane | NSC 600172)
Catalog No. TN13574 Copy Product Info
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Brittonin A, a methoxylated bibenzyl compound discovered in the liverwort F. inouei, exhibits anticancer properties. It demonstrates cytotoxic effects on KB cells and vincristine-resistant KB/VCR cells with IC50 values of 42.1 and 33.7 µM, respectively, as well as on K562 cells and adriamycin-resistant K562/A02 cells with IC50 values of 49.6 and 30.9 µM, respectively. At a concentration of 5 µM, Brittonin A enhances vincristine-induced cell death in KB/VCR cells and adriamycin-induced cell death in K562/A02 cells.
Brittonin A
Copy Product Info🥰Excellent
Catalog No. TN13574
Synonyms 1,2-Bis(3,4,5-trimethoxyphenyl)ethane | NSC 600172
Brittonin A, a methoxylated bibenzyl compound discovered in the liverwort F. inouei, exhibits anticancer properties. It demonstrates cytotoxic effects on KB cells and vincristine-resistant KB/VCR cells with IC50 values of 42.1 and 33.7 µM, respectively, as well as on K562 cells and adriamycin-resistant K562/A02 cells with IC50 values of 49.6 and 30.9 µM, respectively. At a concentration of 5 µM, Brittonin A enhances vincristine-induced cell death in KB/VCR cells and adriamycin-induced cell death in K562/A02 cells.
Brittonin A
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Brittonin A, a methoxylated bibenzyl compound discovered in the liverwort F. inouei, exhibits anticancer properties. It demonstrates cytotoxic effects on KB cells and vincristine-resistant KB/VCR cells with IC50 values of 42.1 and 33.7 µM, respectively, as well as on K562 cells and adriamycin-resistant K562/A02 cells with IC50 values of 49.6 and 30.9 µM, respectively. At a concentration of 5 µM, Brittonin A enhances vincristine-induced cell death in KB/VCR cells and adriamycin-induced cell death in K562/A02 cells. |
| Synonyms | 1,2-Bis(3,4,5-trimethoxyphenyl)ethane | NSC 600172 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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