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AG-494
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Catalog No. T4205Cas No. 133550-35-3
Alias Tyrphostin B48, Tyrphostin AG-494, AG 494
AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.
AG-494
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Purity: 98.69%
Catalog No. T4205Alias Tyrphostin B48, Tyrphostin AG-494, AG 494Cas No. 133550-35-3
AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $53 | In Stock | In Stock | |
| 50 mg | $83 | In Stock | In Stock | |
| 100 mg | $146 | In Stock | In Stock | |
| 200 mg | $208 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.69%
Appearance:Solid
Color:White
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Product Introduction
AG-494 AI Summary
AG-494 is a multifunctional bioactive compound exhibiting a range of inhibitory activities against various targets. It inhibits the epidermal growth factor receptor (EGFR) with an IC50 value ranging from 700.0 nM to 1258.93 nM in human A431 cells and demonstrates inhibitory activity against the ERBB2 receptor with an IC50 value around 41,686.94 nM to 42,000.0 nM. Additionally, it shows antagonistic activity against N-methyl-D-aspartate glutamate receptors 1/2A, 1/2B, and 1/2C with IC50 values exceeding 100,000.0 nM. This compound also inhibits polyGAT phosphorylation with an IC50 of 700.0 nM and cell proliferation in HER14 (human EGFR-overexpressing) cells at concentrations greater than 15,000.0 nM.
In terms of antiviral activity, AG-494 inhibits SARS-CoV-2 induced cytotoxicity in various assays and demonstrates 14.32% inhibition of SARS-CoV-2 3CL-Pro protease at a concentration of 20µM. Against human HDAC6, it shows significant enzymatic inhibition, with inhibition percentages ranging from 58.91% to 93.85%. Furthermore, it engages in multiple bioactivities related to kinase regulation and cellular signaling pathways, which may imply its potential for therapeutic applications across a variety of conditions and diseases..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase. |
| Targets&IC50 | EGFR:0.7 μM (IC50) |
| Synonyms | Tyrphostin B48, Tyrphostin AG-494, AG 494 |
| Molecular Weight | 280.28 |
| Formula | C16H12N2O3 |
| Cas No. | 133550-35-3 |
| Smiles | Oc1ccc(\C=C(/C#N)C(=O)Nc2ccccc2)cc1O |
| Relative Density. | 1.416 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 1.4 mg/mL (5 mM), Sonication is recommended. DMSO: 14 mg/mL (49.95 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.14 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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