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Adenosine-2'-monophosphate

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Catalog No. T20054Cas No. 130-49-4
Alias AMP 2'-phosphate, Adenosine 2'-phosphate, 2'-AMP, 2'-Adenylic acid

Adenosine-2'-monophosphate (2'-AMP) is a nucleoside derived from the conversion of 2’,3'-CAMP. It inhibits inflammatory cytokine production by microglia and suppresses TNF-α and CXCL10 production in activated primary mouse microglia through A2A receptors.

Adenosine-2'-monophosphate

Adenosine-2'-monophosphate

😃Good
Catalog No. T20054Alias AMP 2'-phosphate, Adenosine 2'-phosphate, 2'-AMP, 2'-Adenylic acidCas No. 130-49-4
Adenosine-2'-monophosphate (2'-AMP) is a nucleoside derived from the conversion of 2’,3'-CAMP. It inhibits inflammatory cytokine production by microglia and suppresses TNF-α and CXCL10 production in activated primary mouse microglia through A2A receptors.
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2 mg$525 days
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Product Introduction

Bioactivity
Description
Adenosine-2'-monophosphate (2'-AMP) is a nucleoside derived from the conversion of 2’,3'-CAMP. It inhibits inflammatory cytokine production by microglia and suppresses TNF-α and CXCL10 production in activated primary mouse microglia through A2A receptors.
In vitro
Adenosine-2'-monophosphate (0-100 µM; once daily for 4 days) is able to inhibit the proliferation of pro-glomerular vascular smooth muscle cells and glomerular thylakoid cells through activation of A2B receptors. [1]
Adenosine-2'-monophosphate (30 μM; treatment for 24 h) reduced lipopolysaccharide (LPS, 100 ng/ml)-induced secretion of TNF-α and CXCL10 in primary mouse microglia. [1]
AliasAMP 2'-phosphate, Adenosine 2'-phosphate, 2'-AMP, 2'-Adenylic acid
Chemical Properties
Molecular Weight347.22
FormulaC10H14N5O7P
Cas No.130-49-4
SmilesO(P(=O)(O)O)[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C=3C(N=C2)=C(N)N=CN3
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (115.2 mM), Sonication is recommended.
H2O: 20 mg/mL (57.6 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.8800 mL14.4001 mL28.8002 mL144.0009 mL
5 mM0.5760 mL2.8800 mL5.7600 mL28.8002 mL
10 mM0.2880 mL1.4400 mL2.8800 mL14.4001 mL
20 mM0.1440 mL0.7200 mL1.4400 mL7.2000 mL
50 mM0.0576 mL0.2880 mL0.5760 mL2.8800 mL
DMSO
1mg5mg10mg50mg
100 mM0.0288 mL0.1440 mL0.2880 mL1.4400 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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