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Adenosine-2'-monophosphate

Name: Adenosine-2'-monophosphate
Brand: TargetMol
SKU: T20054
Rating: 4.5 (1 reviews)

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Catalog No. T20054Cas No. 130-49-4

Alias AMP 2'-phosphate, Adenosine 2'-phosphate, 2'-AMP, 2'-Adenylic acid

Adenosine-2'-monophosphate (2'-AMP) is a nucleoside derived from the conversion of 2',3'-CAMP. It inhibits inflammatory cytokine production by microglia and suppresses TNF-α and CXCL10 production in activated primary mouse microglia through A2A receptors.

Adenosine-2'-monophosphate

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Purity: 99.88%

Catalog No. T20054Alias AMP 2'-phosphate, Adenosine 2'-phosphate, 2'-AMP, 2'-Adenylic acidCas No. 130-49-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$52	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA MS HNMR HPLC PNMR

Product Introduction

Bioactivity

Description	Adenosine-2'-monophosphate (2'-AMP) is a nucleoside derived from the conversion of 2',3'-CAMP. It inhibits inflammatory cytokine production by microglia and suppresses TNF-α and CXCL10 production in activated primary mouse microglia through A2A receptors.
In vitro	Adenosine-2'-monophosphate (0-100 µM; once daily for 4 days) is able to inhibit the proliferation of pro-glomerular vascular smooth muscle cells and glomerular thylakoid cells through activation of A2B receptors. [1] Adenosine-2'-monophosphate (30 μM; treatment for 24 h) reduced lipopolysaccharide (LPS, 100 ng/ml)-induced secretion of TNF-α and CXCL10 in primary mouse microglia. [1]
Synonyms	AMP 2'-phosphate, Adenosine 2'-phosphate, 2'-AMP, 2'-Adenylic acid

Chemical Properties

Molecular Weight	347.22
Formula	C₁₀H₁₄N₅O₇P
Cas No.	130-49-4
Smiles	O(P(=O)(O)O)[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C=3C(N=C2)=C(N)N=CN3
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (115.2 mM), Sonication is recommended.

H2O: 20 mg/mL (57.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8800 mL	14.4001 mL	28.8002 mL	144.0009 mL
5 mM	0.5760 mL	2.8800 mL	5.7600 mL	28.8002 mL
10 mM	0.2880 mL	1.4400 mL	2.8800 mL	14.4001 mL
20 mM	0.1440 mL	0.7200 mL	1.4400 mL	7.2000 mL
50 mM	0.0576 mL	0.2880 mL	0.5760 mL	2.8800 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0288 mL	0.1440 mL	0.2880 mL	1.4400 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc