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Adenosine-2'-monophosphate

Name: Adenosine-2'-monophosphate
Brand: TargetMol
SKU: T20054
Rating: 4.5 (1 reviews)

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Catalog No. T20054Cas No. 130-49-4

Alias AMP 2'-phosphate, Adenosine 2'-phosphate, 2'-AMP, 2'-Adenylic acid

Adenosine-2'-monophosphate (2'-AMP) is a nucleoside derived from the conversion of 2',3'-CAMP. It inhibits inflammatory cytokine production by microglia and suppresses TNF-α and CXCL10 production in activated primary mouse microglia through A2A receptors.

Adenosine-2'-monophosphate

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Catalog No. T20054Alias AMP 2'-phosphate, Adenosine 2'-phosphate, 2'-AMP, 2'-Adenylic acidCas No. 130-49-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$52	5 days	5 days

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Expected start date of shipmentUSA Warehouse [1-2 days] Global Warehouse [5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Adenosine-2'-monophosphate (2'-AMP) is a nucleoside derived from the conversion of 2',3'-CAMP. It inhibits inflammatory cytokine production by microglia and suppresses TNF-α and CXCL10 production in activated primary mouse microglia through A2A receptors.
In vitro	Adenosine-2'-monophosphate (0-100 µM; once daily for 4 days) is able to inhibit the proliferation of pro-glomerular vascular smooth muscle cells and glomerular thylakoid cells through activation of A2B receptors. [1] Adenosine-2'-monophosphate (30 μM; treatment for 24 h) reduced lipopolysaccharide (LPS, 100 ng/ml)-induced secretion of TNF-α and CXCL10 in primary mouse microglia. [1]
Synonyms	AMP 2'-phosphate, Adenosine 2'-phosphate, 2'-AMP, 2'-Adenylic acid

Chemical Properties

Molecular Weight	347.22
Formula	C₁₀H₁₄N₅O₇P
Cas No.	130-49-4
Smiles	O(P(=O)(O)O)[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C=3C(N=C2)=C(N)N=CN3
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (115.2 mM), Sonication is recommended.

H2O: 20 mg/mL (57.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8800 mL	14.4001 mL	28.8002 mL	144.0009 mL
5 mM	0.5760 mL	2.8800 mL	5.7600 mL	28.8002 mL
10 mM	0.2880 mL	1.4400 mL	2.8800 mL	14.4001 mL
20 mM	0.1440 mL	0.7200 mL	1.4400 mL	7.2000 mL
50 mM	0.0576 mL	0.2880 mL	0.5760 mL	2.8800 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0288 mL	0.1440 mL	0.2880 mL	1.4400 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc