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Cholesteryl Hemisuccinate

Catalog No. T67509 CAS 1510-21-0

Synonyms: Cholesterol hydrogen succinate

Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, anticancer and tumour growth inhibiting properties. Cholesteryl Hemisuccinate inhibits the hepatotoxicity of acetaminophen and prevents AAP-induced apoptosis and necrosis in hepatocytes. Cholesteryl Hemisuccinate inhibits DNA polymerase and DNA topoisomerase, thereby inhibiting DNA replication and repair as well as cell division.

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Cholesteryl Hemisuccinate Chemical Structure

Cholesteryl Hemisuccinate, CAS 1510-21-0

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500 mg	In stock	$ 45.00

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Purity: 99.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, anticancer and tumour growth inhibiting properties. Cholesteryl Hemisuccinate inhibits the hepatotoxicity of acetaminophen and prevents AAP-induced apoptosis and necrosis in hepatocytes. Cholesteryl Hemisuccinate inhibits DNA polymerase and DNA topoisomerase, thereby inhibiting DNA replication and repair as well as cell division.
In vitro	Cholesteryl Hemisuccinate (0-1000 μM) inhibited the growth of MCF-7 and MCF-10A cells.[3]
In vivo	Cholesteryl Hemisuccinate (100 mg/kg ; ip ; single administration before AAP) eliminated AAP-induced apoptosis and necrosis in ICR mice (CD-1) for histological and biochemical diagnosis.[1]

Synonyms	Cholesterol hydrogen succinate
Molecular Weight	486.73
Formula	C31H50O4
CAS No.	1510-21-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 22.5 mg/mL (46.2 mM ), Sonication is recommended.

References and Literature

1. Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 ; 279(3):1470-1483. 2. Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015 ; 2015:746093. 3. Djuric Z, et al. Growth inhibition of MCF-7 and MCF-10A human breast cells by alpha-tocopheryl hemisuccinate, cholesteryl hemisuccinate and their ether analogs. Cancer Lett. 1997 ; 111(1-2):133-139. 4. Pajor L, et al. Cholesteryl hemisuccinate's inductive effect on membrane rigidization regarding both, its remodelling of the cells' surface receptor pattern and its decreasing the natural killer susceptibility of K-562 cells. Acta Biol Hung. 1991 ; 42(4):371-383. 5. Yamamoto Y, et al. Relationship between Thylakoid Membrane Fluidity and the Functioning of Pea Chloroplasts : EFFECT OF CHOLESTERYL HEMISUCCINATE. Plant Physiol. 1981 ; 67(6):1069-1072.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library DNA Damage & Repair Compound Library Bioactive Compound Library

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Keywords

Cholesteryl Hemisuccinate 1510-21-0 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis Topoisomerase Cholesterol hydrogen succinate Cholesteryl Cholesterol hydrogen Succinate inhibitor inhibit

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