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Thiamine pyrophosphate tetrahydrate is the coenzyme form of vitamin B1 and acts as a crucial intermediate in the pyruvate dehydrogenase complex and alpha-ketoglutarate dehydrogenase complex. It functions as a cofactor for α-keto acid dehydrogenases, which are essential for oxidative phosphorylation and the pentose phosphate pathway.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
| Description | Thiamine pyrophosphate tetrahydrate is the coenzyme form of vitamin B1 and acts as a crucial intermediate in the pyruvate dehydrogenase complex and alpha-ketoglutarate dehydrogenase complex. It functions as a cofactor for α-keto acid dehydrogenases, which are essential for oxidative phosphorylation and the pentose phosphate pathway. |
| In vivo | Thiamine pyrophosphate (25 mg/kg, intraperitoneal injection) tetrahydrate inhibits oxidative damage induced by ischemia-reperfusion in rat ovarian tissue. Additionally, thiamine pyrophosphate (20 mg/kg, intraperitoneal injection, once daily for 14 days) tetrahydrate prevents cisplatin-induced cardiotoxicity in rats, as well as the associated oxidative stress and cardiac injury. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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