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Napitane
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Catalog No. T26363LCas No. 148152-63-0
Alias ABT 200, A-75200, A75200, A 75200
napitane (A 75200) is a novel catecholamine uptake inhibitor with inhibitory effects on α-adrenergic receptors and potential antidepressant activity for the study of depression.
Napitane
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Purity: 99.89%
Catalog No. T26363LAlias ABT 200, A-75200, A75200, A 75200Cas No. 148152-63-0
napitane (A 75200) is a novel catecholamine uptake inhibitor with inhibitory effects on α-adrenergic receptors and potential antidepressant activity for the study of depression.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $197 | - | In Stock | |
| 5 mg | $479 | - | In Stock | |
| 10 mg | $678 | - | In Stock | |
| 25 mg | $1,030 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information
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Purity:99.89%
ee:99.89%
Appearance:Oil
Color:Transparent to Yellow
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Product Introduction
Napitane AI Summary
Napitane exhibits significant bioactivity across various adrenergic receptors. It demonstrates an in vitro binding affinity for the Alpha-1 adrenergic receptor with a Ki of 106.0 nM. For the Alpha-2 adrenergic receptor in rat cortex, it shows a much higher binding affinity with a Ki of 0.428 nM. It functions as an antagonist at presynaptic Alpha-2 adrenergic receptors in the rat vas deferens, exhibiting a Kd of 16.6 nM, and as an antagonist at postsynaptic Alpha-2 adrenergic receptors in the dog saphenous vein with a Kd of 5.623 nM. Additionally, Napitane inhibits norepinephrine reuptake in synaptosomal rat hypothalamic preparations with an IC50 of 3110.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | napitane (A 75200) is a novel catecholamine uptake inhibitor with inhibitory effects on α-adrenergic receptors and potential antidepressant activity for the study of depression. |
| Synonyms | ABT 200, A-75200, A75200, A 75200 |
| Molecular Weight | 335.44 |
| Formula | C22H25NO2 |
| Cas No. | 148152-63-0 |
| Smiles | C([C@H]1C2=C(C3=C(C=C2)OCO3)CCC1)N4C[C@H](CC4)C5=CC=CC=C5 |
| Relative Density. | 1.31g/cm3 |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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