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2,4,6-Triiodophenol

Name: 2,4,6-Triiodophenol
Brand: TargetMol
SKU: T8628
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8628Cas No. 609-23-4

2,4,6-Triiodophenol is used as an iodinated disinfection by product formed during chlorination of sewage effluents. It is also used as a potent thyroid disrupting chemical and to investigate deiodinase

2,4,6-Triiodophenol

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Purity: 98.11%

Catalog No. T8628Cas No. 609-23-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$46	In Stock	In Stock
25 mg	$57	In Stock	In Stock
50 mg	$72	In Stock	In Stock
100 mg	$89	In Stock	In Stock
500 mg	$219	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.11%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

2,4,6-Triiodophenol AI Summary

2,4,6-Triiodophenol exhibits a range of bioactivities, primarily related to thyroxine binding and inhibition of TTR-mediated fibrillogenesis. It shows a binding affinity of 384.0 in a competition binding assay against prealbumin, relative to L-T4 (100), and a thyroxine binding constant on human plasma prealbumin of KT4 = 7.39E-7 M-1, with a KPCB value of 0.0000075 M-1. Its KPCB/K352 ratio of 33.8 highlights its competitive effectiveness. In rat liver assays, it has a relative binding affinity for thyroxin binding prealbumin (TBPA) that is 10.15 times that of T4, and for nuclear receptors, it is 0.27 times that of T4. In terms of inhibiting TTR-mediated fibrillogenesis, 2,4,6-Triiodophenol has an IC50 of 3200.0 nM and achieves 80.0% inhibition relative to the control. Additionally, 2,4,6-Triiodophenol displays significant antimicrobial and antiparasitic activities against Cryptosporidium parvum, achieving between 36.0% to 99.6% growth inhibition in infected HCT8 cells depending on concentration and timing. It also has antiviral properties, inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 uM, albeit with variable inhibition rates of -2.63% and 0.15%, respectively. It shows 7.667% inhibition of SARS-CoV-2 3CL-Pro protease at 20µM, suggesting potential efficacy in disrupting viral replication. Lastly, 2,4,6-Triiodophenol displays a moderate inhibitory effect on human HDAC6 enzyme activity, with differing inhibition levels of 29.72% using a commercial peptide substrate and -19.41% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	471.8
Formula	C₆H₃I₃O
Cas No.	609-23-4
Smiles	Oc1c(I)cc(I)cc1I
Relative Density.	2.8493 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (47.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1195 mL	10.5977 mL	21.1954 mL	105.9771 mL
5 mM	0.4239 mL	2.1195 mL	4.2391 mL	21.1954 mL
10 mM	0.2120 mL	1.0598 mL	2.1195 mL	10.5977 mL
20 mM	0.1060 mL	0.5299 mL	1.0598 mL	5.2989 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc