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Enloplatin

Name: Enloplatin
Brand: TargetMol
SKU: T68065
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68065Cas No. 111523-41-2

Enloplatin is a carboplatin analog that has a partial role in advanced ovarian cancer.

Enloplatin

😃Good

Purity: 98.76%

Catalog No. T68065Cas No. 111523-41-2

Enloplatin is a carboplatin analog that has a partial role in advanced ovarian cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
5 mg	$74	In Stock	In Stock
10 mg	$109	In Stock	In Stock
25 mg	$212	In Stock	In Stock
50 mg	$289	In Stock	In Stock
100 mg	$428	-	In Stock
200 mg	$612	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.76%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Enloplatin is a carboplatin analog that has a partial role in advanced ovarian cancer.
Targets&IC50	Tera (cells):7.2 µM
In vivo	Enloplatin (i.v. infusion; over 1.5 h; every 21 days), one patient had a partial response (6%; 95% CI 0-26%) lasting 2.8 months. The median survival was 9.4 months (95%; CI 5.1-19.7%). Neutropenia was the dose-limiting toxicity. Nephrotoxicity was manageable. Enloplatin is the major form of the free drug in plasma. However, 13.5 h after initiation of treatment, 85% of the drug in plasma is protein bound. Elimination of the drug is mainly renal.[1]

Chemical Properties

Molecular Weight	481.4
Formula	C₁₃H₂₂N₂O₅Pt
Cas No.	111523-41-2
Smiles	O=C1C2(C(=O)[O-][Pt+2]3([O-]1)[NH2]CC4(C[NH2]3)CCOCC4)CCC2

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (114.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0773 mL	10.3864 mL	20.7727 mL	103.8637 mL
5 mM	0.4155 mL	2.0773 mL	4.1545 mL	20.7727 mL
10 mM	0.2077 mL	1.0386 mL	2.0773 mL	10.3864 mL
20 mM	0.1039 mL	0.5193 mL	1.0386 mL	5.1932 mL
50 mM	0.0415 mL	0.2077 mL	0.4155 mL	2.0773 mL
100 mM	0.0208 mL	0.1039 mL	0.2077 mL	1.0386 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc