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Alendronate sodium
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Catalog No. T22559 Copy Product Info
Purity: 99.94%
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Alendronate sodium is a nitrogen-containing bisphosphonate that inhibits bone resorption. Alendronate sodium interferes with the mevalonate pathway by inhibiting farnesyl-3-phosphate (FPP) synthase in osteoclasts, thereby blocking osteoclast activity and inducing their apoptosis. Sodium alendronate is used in the treatment of metabolic bone diseases such as osteoporosis and Paget’s disease of bone.
Cas No. 129318-43-0
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 mg | $29 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.94%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Alendronate sodium is a nitrogen-containing bisphosphonate that inhibits bone resorption. Alendronate sodium interferes with the mevalonate pathway by inhibiting farnesyl-3-phosphate (FPP) synthase in osteoclasts, thereby blocking osteoclast activity and inducing their apoptosis. Sodium alendronate is used in the treatment of metabolic bone diseases such as osteoporosis and Paget’s disease of bone. |
| In vivo | Methods: Female C57BL/6 mice received titanium alloy implants in the proximal right tibia. Postoperatively, they were administered intraperitoneal injections of alendronate sodium (73 μg/kg/day, 5 days per week) for 28 consecutive days. Results: Alendronate sodium significantly increased mechanical strength at the bone-implant interface, significantly accelerated bone formation, and inhibited osteoclast activity. [3] |
| Molecular Weight | 271.08 |
| Formula | C4H12NNaO7P2 |
| Cas No. | 129318-43-0 |
| Smiles | O=P(C(P(O)([O-])=O)(O)CCCN)(O)O.[Na+] |
| Relative Density. | no data available |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: <1 mg/mL H2O: 20 mg/mL (73.78 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Alendronate sodium chemical structure | Alendronate sodium in vivo | Alendronate sodium formula | Alendronate sodium molecular weight
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