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Gamma-Glutamylcysteine

Name: Gamma-Glutamylcysteine
Brand: TargetMol
SKU: T38024
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38024Cas No. 636-58-8

Alias γ-Glu-Cys

Gamma-Glutamylcysteine is a natural dipeptide containing cysteine and glutamic acid, serving as a precursor to glutathione (GSH) and a cofactor for glutathione peroxidase (GPx). Gamma-Glutamylcysteine exhibits anti-inflammatory effects by upregulating IL-10 whilst downregulating TNF-α, IL-6, and IL-1β.

Gamma-Glutamylcysteine

😃Good

Catalog No. T38024Alias γ-Glu-CysCas No. 636-58-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$29	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Gamma-Glutamylcysteine is a natural dipeptide containing cysteine and glutamic acid, serving as a precursor to glutathione (GSH) and a cofactor for glutathione peroxidase (GPx). Gamma-Glutamylcysteine exhibits anti-inflammatory effects by upregulating IL-10 whilst downregulating TNF-α, IL-6, and IL-1β.
In vitro	Gamma-Glutamylcysteine (200 μM) was used to pre-incubate Homo sapiens astrocyte-like cells for 15 minutes, followed by treatment with Aβ40 oligomers (10 nM). After 24 hours, relevant biochemical indicators were measured. The research results indicate that Gamma-Glutamylcysteine can alleviate Aβ40 oligomer-induced oxidative damage and neuroinflammation by increasing GSH levels and reducing the GSSG/GSH ratio [1].
Synonyms	γ-Glu-Cys

Chemical Properties

Molecular Weight	250.27
Formula	C₈H₁₄N₂O₅S
Cas No.	636-58-8
Smiles	[C@@H](NC(CC[C@@H](C(O)=O)N)=O)(C(O)=O)CS

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: ≥ 54.8 mg/mL, Sonication is recommended.

DMSO: ≥ 52 mg/mL, Sonication is recommended.

H2O: 80 mg/mL (319.65 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.9957 mL	19.9784 mL	39.9568 mL	199.7842 mL
5 mM	0.7991 mL	3.9957 mL	7.9914 mL	39.9568 mL
10 mM	0.3996 mL	1.9978 mL	3.9957 mL	19.9784 mL
20 mM	0.1998 mL	0.9989 mL	1.9978 mL	9.9892 mL
50 mM	0.0799 mL	0.3996 mL	0.7991 mL	3.9957 mL
100 mM	0.0400 mL	0.1998 mL	0.3996 mL	1.9978 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc