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N-methyl Leukotriene C4

Catalog No. T37980 CAS 131391-65-6

Synonyms: N-methyl Leukotriene C4

Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and < 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.

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N-methyl Leukotriene C4 Chemical Structure

N-methyl Leukotriene C4, CAS 131391-65-6

Pack Size	Availability	Price/USD
25 μg	35 days	$ 413.00
50 μg	35 days	$ 783.00
100 μg	35 days	$ 1,480.00

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Description

Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice.

Synonyms	N-methyl Leukotriene C4
Molecular Weight	639.8
Formula	C31H49N3O9S
CAS No.	131391-65-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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DMF: 50 mg/mL

DMSO: 50 mg/mL

PBS (pH 7.2): 100 μg/mL

Ethanol:H2O (95:5): 2 mg/mL

Ethanol: 1 mg/mL

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Keywords

N-methyl Leukotriene C4 131391-65-6 N methyl Leukotriene C4 N-methyl Leukotriene C-4 Nmethyl Leukotriene C4 inhibitor inhibit

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