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Avenanthramide C

🥰Excellent
Catalog No. TN8322Cas No. 116764-15-9

Avenanthramide C is an orally available natural alkaloid with antioxidant/inflammatory properties that reduces the expression of TNF-a, BAK, IL-1b, and Bcl-2; reverses memory and behavioral deficits in Alzheimer's disease, with a reduction in caspase-3 cleavage and an increase in levels of pS9GSK-3β and IL-10, is able to bind α1A adrenergic and stimulate AMPK; can attenuate noise and drug-induced hearing loss.

Avenanthramide C

Avenanthramide C

🥰Excellent
Purity: 99.4%
Catalog No. TN8322Cas No. 116764-15-9
Avenanthramide C is an orally available natural alkaloid with antioxidant/inflammatory properties that reduces the expression of TNF-a, BAK, IL-1b, and Bcl-2; reverses memory and behavioral deficits in Alzheimer's disease, with a reduction in caspase-3 cleavage and an increase in levels of pS9GSK-3β and IL-10, is able to bind α1A adrenergic and stimulate AMPK; can attenuate noise and drug-induced hearing loss.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$35-In Stock
5 mg$81-In Stock
10 mg$129-In Stock
25 mg$219-In Stock
50 mg$326-In Stock
100 mg$485-In Stock
200 mg$693-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.4%
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Product Introduction

Bioactivity
Description
Avenanthramide C is an orally available natural alkaloid with antioxidant/inflammatory properties that reduces the expression of TNF-a, BAK, IL-1b, and Bcl-2; reverses memory and behavioral deficits in Alzheimer's disease, with a reduction in caspase-3 cleavage and an increase in levels of pS9GSK-3β and IL-10, is able to bind α1A adrenergic and stimulate AMPK; can attenuate noise and drug-induced hearing loss.
In vitro
In RAW264.7 macrophages, Avenanthramide C (0-50 μM, 24 h) significantly inhibits LPS/ATP-induced ROS production, mitochondrial membrane potential loss, membrane permeability increase, and IL-1β secretion. Avenanthramide C also downregulates the expression of NLRP3, Caspase-1, GSDMD, and IL-1β proteins, indicating suppression of ROS-mediated mitochondrial damage and pyroptosis via the PI3K/Akt pathway[1].
In vivo
In an LPS-induced acute inflammation mouse model, a single intraperitoneal injection of Avenanthramide C (20 mg/kg) significantly reduces IL-1β levels in peritoneal fluid and downregulates NLRP3 and GSDMD expression, demonstrating its anti-inflammatory and anti-pyroptotic effects in vivo[1].
Chemical Properties
Molecular Weight315.28
FormulaC16H13NO6
Cas No.116764-15-9
SmilesN(C(/C=C/C1=CC(O)=C(O)C=C1)=O)C2=C(C(O)=O)C=C(O)C=C2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (126.87 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.34 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1718 mL15.8589 mL31.7178 mL158.5892 mL
5 mM0.6344 mL3.1718 mL6.3436 mL31.7178 mL
10 mM0.3172 mL1.5859 mL3.1718 mL15.8589 mL
20 mM0.1586 mL0.7929 mL1.5859 mL7.9295 mL
50 mM0.0634 mL0.3172 mL0.6344 mL3.1718 mL
100 mM0.0317 mL0.1586 mL0.3172 mL1.5859 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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