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Avenanthramide C
🥰Excellent
Catalog No. TN8322Cas No. 116764-15-9
Avenanthramide C is an orally available natural alkaloid with antioxidant/inflammatory properties that reduces the expression of TNF-a, BAK, IL-1b, and Bcl-2; reverses memory and behavioral deficits in Alzheimer's disease, with a reduction in caspase-3 cleavage and an increase in levels of pS9GSK-3β and IL-10, is able to bind α1A adrenergic and stimulate AMPK; can attenuate noise and drug-induced hearing loss.
Avenanthramide C
🥰Excellent
Purity: 99.4%
Catalog No. TN8322Cas No. 116764-15-9
Avenanthramide C is an orally available natural alkaloid with antioxidant/inflammatory properties that reduces the expression of TNF-a, BAK, IL-1b, and Bcl-2; reverses memory and behavioral deficits in Alzheimer's disease, with a reduction in caspase-3 cleavage and an increase in levels of pS9GSK-3β and IL-10, is able to bind α1A adrenergic and stimulate AMPK; can attenuate noise and drug-induced hearing loss.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $46 | In Stock | |
| 5 mg | $103 | In Stock | |
| 10 mg | $150 | In Stock | |
| 25 mg | $250 | In Stock | |
| 50 mg | $370 | In Stock | |
| 100 mg | $550 | In Stock | |
| 200 mg | $788 | In Stock |
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Purity:99.4%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Avenanthramide C is an orally available natural alkaloid with antioxidant/inflammatory properties that reduces the expression of TNF-a, BAK, IL-1b, and Bcl-2; reverses memory and behavioral deficits in Alzheimer's disease, with a reduction in caspase-3 cleavage and an increase in levels of pS9GSK-3β and IL-10, is able to bind α1A adrenergic and stimulate AMPK; can attenuate noise and drug-induced hearing loss. |
| In vitro | In RAW264.7 macrophages, Avenanthramide C (0-50 μM, 24 h) significantly inhibits LPS/ATP-induced ROS production, mitochondrial membrane potential loss, membrane permeability increase, and IL-1β secretion. Avenanthramide C also downregulates the expression of NLRP3, Caspase-1, GSDMD, and IL-1β proteins, indicating suppression of ROS-mediated mitochondrial damage and pyroptosis via the PI3K/Akt pathway[1]. |
| In vivo | In an LPS-induced acute inflammation mouse model, a single intraperitoneal injection of Avenanthramide C (20 mg/kg) significantly reduces IL-1β levels in peritoneal fluid and downregulates NLRP3 and GSDMD expression, demonstrating its anti-inflammatory and anti-pyroptotic effects in vivo[1]. |
| Molecular Weight | 315.28 |
| Formula | C16H13NO6 |
| Cas No. | 116764-15-9 |
| Smiles | N(C(/C=C/C1=CC(O)=C(O)C=C1)=O)C2=C(C(O)=O)C=C(O)C=C2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (126.87 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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