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Diclofenac Amide

Name: Diclofenac Amide
Brand: TargetMol
SKU: T0643
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0643Cas No. 15362-40-0

Diclofenac Amide is used as a intermediates of Diclofenac.

Diclofenac Amide

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Purity: 98.80%

Catalog No. T0643Cas No. 15362-40-0

Diclofenac Amide is used as a intermediates of Diclofenac.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.80%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Diclofenac Amide AI Summary

Diclofenac Amide exhibits significant bioactivities and cytotoxic properties. It is potent in inhibiting histone lysine methyltransferase G9a, the malarial parasite plastid, HP1-beta chromodomain interactions, GLP-1 receptor as an inverse agonist, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). It also shows growth inhibition in multiple human tumor cell lines including renal, non-small cell lung, melanoma, leukemia, central nervous system, ovarian, colon, and small cell lung cancers. Additionally, it demonstrates cytotoxicity against human cell lines such as SW620, B16F10, L-132, HuTu 80, MIAPaCa2, and MCF7 with an effective dose (ED50) generally greater than 100.0 μg/ml, except for KB cells where the ED50 is exactly 100.0 μg/ml..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Diclofenac Amide is used as a intermediates of Diclofenac.

Chemical Properties

Molecular Weight	278.13
Formula	C₁₄H₉Cl₂NO
Cas No.	15362-40-0
Smiles	Clc1cccc(Cl)c1N1C(=O)Cc2ccccc12
Relative Density.	1.432 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (179.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5954 mL	17.9772 mL	35.9544 mL	179.7720 mL
5 mM	0.7191 mL	3.5954 mL	7.1909 mL	35.9544 mL
10 mM	0.3595 mL	1.7977 mL	3.5954 mL	17.9772 mL
20 mM	0.1798 mL	0.8989 mL	1.7977 mL	8.9886 mL
50 mM	0.0719 mL	0.3595 mL	0.7191 mL	3.5954 mL
100 mM	0.0360 mL	0.1798 mL	0.3595 mL	1.7977 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc