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SRI 37892

Name: SRI 37892
Brand: TargetMol
SKU: T9662
Price: 347 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9662Cas No. 1030769-75-5

SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.

SRI 37892

🥰Excellent

Purity: 99.93%

Catalog No. T9662Cas No. 1030769-75-5

SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$347	In Stock	In Stock
5 mg	$870	In Stock	In Stock
10 mg	$1,170	In Stock	In Stock
25 mg	$1,730	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$948	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.
In vitro	SRI37892 block Wnt/β-catenin signaling in HEK293 cells induced by Wnt3A and LRP6 with IC50 of 0.66 μM and 0.78 μM, respectively[1].

Chemical Properties

Molecular Weight	465.53
Formula	C₂₆H₁₉N₅O₂S
Cas No.	1030769-75-5
Smiles	C(NC1=NC(=CS1)C=2C=C3C(=CC2)NC(=O)CC3)(=O)C4=CC=C(N5C=6C(N=C5)=CC=CC6)C=C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (107.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1481 mL	10.7404 mL	21.4809 mL	107.4045 mL
5 mM	0.4296 mL	2.1481 mL	4.2962 mL	21.4809 mL
10 mM	0.2148 mL	1.0740 mL	2.1481 mL	10.7404 mL
20 mM	0.1074 mL	0.5370 mL	1.0740 mL	5.3702 mL
50 mM	0.0430 mL	0.2148 mL	0.4296 mL	2.1481 mL
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0740 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc