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SRI 37892

Name: SRI 37892
Brand: TargetMol
SKU: T9662
Price: 347 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9662Cas No. 1030769-75-5

SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.

SRI 37892

🥰Excellent

Purity: 99.93%

Catalog No. T9662Cas No. 1030769-75-5

SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.

Pack Size	Price	Availability
1 mg	$347	In Stock
5 mg	$870	In Stock
10 mg	$1,170	In Stock
25 mg	$1,730	In Stock
1 mL x 10 mM (in DMSO)	$948	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.93%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.
In vitro	SRI37892 block Wnt/β-catenin signaling in HEK293 cells induced by Wnt3A and LRP6 with IC50 of 0.66 μM and 0.78 μM, respectively[1].

Chemical Properties

Molecular Weight	465.53
Formula	C₂₆H₁₉N₅O₂S
Cas No.	1030769-75-5
Smiles	C(NC1=NC(=CS1)C=2C=C3C(=CC2)NC(=O)CC3)(=O)C4=CC=C(N5C=6C(N=C5)=CC=CC6)C=C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (107.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1481 mL	10.7404 mL	21.4809 mL	107.4045 mL
5 mM	0.4296 mL	2.1481 mL	4.2962 mL	21.4809 mL
10 mM	0.2148 mL	1.0740 mL	2.1481 mL	10.7404 mL
20 mM	0.1074 mL	0.5370 mL	1.0740 mL	5.3702 mL
50 mM	0.0430 mL	0.2148 mL	0.4296 mL	2.1481 mL
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0740 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc