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Lunularin

Name: Lunularin
Brand: TargetMol
SKU: T32959
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T32959Cas No. 37116-80-6

Lunularin is a naturally occurring bibenzyl compound widely distributed in liverworts (such as Conocephalum conicum) and is also a major gut microbiota-derived metabolite of resveratrol. Research indicates that Lunularin possesses significant antioxidant and anti-inflammatory properties and can selectively inhibit 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1). Due to its role in regulating glucocorticoid activation and metabolic homeostasis, this molecule is of great interest in studies involving metabolic diseases, skin health, and neuroprotection.

Lunularin

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Purity: 99.94%

Catalog No. T32959Cas No. 37116-80-6

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	-	In Stock
50 mg	$40	-	In Stock
100 mg	$56	-	In Stock
500 mg	$208	-	In Stock
1 mL x 10 mM (in DMSO)	$62	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Lunularin is a naturally occurring bibenzyl compound widely distributed in liverworts (such as Conocephalum conicum) and is also a major gut microbiota-derived metabolite of resveratrol. Research indicates that Lunularin possesses significant antioxidant and anti-inflammatory properties and can selectively inhibit 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1). Due to its role in regulating glucocorticoid activation and metabolic homeostasis, this molecule is of great interest in studies involving metabolic diseases, skin health, and neuroprotection.
In vitro	Lunularin demonstrates potent and selective inhibitory activity against human and rat 11beta-HSD1 in cell-based assays and exhibits strong radical scavenging capabilities to reduce oxidative stress [2][3].
In vivo	In animal models, Lunularin contributes significantly to the health-promoting effects of resveratrol, showing the potential to regulate metabolic parameters and mitigate systemic inflammation [2].

Chemical Properties

Molecular Weight	214.26
Formula	C₁₄H₁₄O₂
Cas No.	37116-80-6
Smiles	OC1=CC=C(C=C1)CCC=2C=CC=C(O)C2
Relative Density.	1.191g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (373.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6672 mL	23.3361 mL	46.6723 mL	233.3613 mL
5 mM	0.9334 mL	4.6672 mL	9.3345 mL	46.6723 mL
10 mM	0.4667 mL	2.3336 mL	4.6672 mL	23.3361 mL
20 mM	0.2334 mL	1.1668 mL	2.3336 mL	11.6681 mL
50 mM	0.0933 mL	0.4667 mL	0.9334 mL	4.6672 mL
100 mM	0.0467 mL	0.2334 mL	0.4667 mL	2.3336 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Lunularin