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Neophytadiene

Name: Neophytadiene
Brand: TargetMol
SKU: T40586
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40586Cas No. 504-96-1

Neophytadiene is a diterpene compound extracted from Turbinaria ornate, with anti-inflammatory, antidepressant, anxiolytic-like, anticonvulsant, antioxidant, and cardioprotective effects. It inhibits LPS-induced inflammation in RAW 264.7 macrophages and Sprague-Dawley rats and can be used in neurological disease research.

Neophytadiene

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Purity: 99.05%

Catalog No. T40586Cas No. 504-96-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	-	In Stock
5 mg	$129	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$342	In Stock	In Stock
50 mg	$497	-	In Stock
100 mg	$727	-	In Stock
200 mg	$980	-	In Stock
1 mL x 10 mM (in DMSO)	$123	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.05%

Color:Transparent

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Neophytadiene is a diterpene compound extracted from Turbinaria ornate, with anti-inflammatory, antidepressant, anxiolytic-like, anticonvulsant, antioxidant, and cardioprotective effects. It inhibits LPS-induced inflammation in RAW 264.7 macrophages and Sprague-Dawley rats and can be used in neurological disease research.
In vitro	Neophytadiene has an IC50 value of 50 μM for RAW 264.7 cells. Neophytadiene (25, 50, and 100 μM) pretreated LPS-induced RAW 264.7 cells to inhibit NO production and down-regulate the production of inducable nitric oxide synthase (iNOS). Neophytadiene (25, 50, and 100 μM) significantly reduced the production of TNF-α and NF-κB proteins in LPS-induced cells. [1]
In vivo	Neophytadiene (12, 25, and 50 mg/kg, orally administered once daily for 7 days) showed that Neophytadiene improved CKMB levels in LPS treated rats in a dose-dependent manner. Restores SOD and catalase activity and reduces levels of pro-inflammatory cytokines such as IL1β, IL6 and IL10. [1]

Chemical Properties

Molecular Weight	278.52
Formula	C₂₀H₃₈
Cas No.	504-96-1
Smiles	C=CC(=C)CCCC(C)CCCC(C)CCCC(C)C

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (897.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5904 mL	17.9520 mL	35.9041 mL	179.5203 mL
5 mM	0.7181 mL	3.5904 mL	7.1808 mL	35.9041 mL
10 mM	0.3590 mL	1.7952 mL	3.5904 mL	17.9520 mL
20 mM	0.1795 mL	0.8976 mL	1.7952 mL	8.9760 mL
50 mM	0.0718 mL	0.3590 mL	0.7181 mL	3.5904 mL
100 mM	0.0359 mL	0.1795 mL	0.3590 mL	1.7952 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc