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Oxyphencyclimine Hydrochloride
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Catalog No. T2138Cas No. 125-52-0
Alias Ulcociclinina, Spazamin, Daricon
Oxyphencyclimine Hydrochloride (Ulcociclinina) is a synthetic tertiary amine and antimuscarinic agent with antispasmodic and antisecretory activities.
Oxyphencyclimine Hydrochloride
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Purity: 99.55%
Catalog No. T2138Alias Ulcociclinina, Spazamin, DariconCas No. 125-52-0
Oxyphencyclimine Hydrochloride (Ulcociclinina) is a synthetic tertiary amine and antimuscarinic agent with antispasmodic and antisecretory activities.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $33 | In Stock | In Stock | |
| 5 mg | $51 | In Stock | In Stock | |
| 10 mg | $89 | In Stock | In Stock | |
| 25 mg | Preferential | In Stock | In Stock | |
| 50 mg | Preferential | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.55%
Appearance:Solid
Color:White
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Product Introduction
Oxyphencyclimine Hydrochloride AI Summary
Oxyphencyclimine Hydrochloride exhibits diverse bioactivities across multiple targets. It shows potency in modulating Lamin A splicing with values of 3548.1 nM and 19952.6 nM. It functions as an influenza NS1 protein inhibitor with a potency of 316.2 nM and modulates Cytochrome P450 3A4 both as an activator and inhibitor at 7943.3 nM. It inhibits the malarial parasite plastid with potencies ranging from 14381.8 nM to 19011.5 nM and demonstrates an inhibition of RanGTP-induced Rango - Importin beta complex dissociation at 32642.7 nM. In normal breast cells, it induces DNA re-replication with a potency of 461.1 nM and inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies from 11220.2 nM to 25929.0 nM. Furthermore, it exhibits antiviral activities by blocking cell entry for Marburg Virus and Ebola Virus, with activity observed at both micromolar and nanomolar ranges. It inhibits sodium fluorescein uptake significantly in OATP1B1- and OATP1B3-transfected CHO cells, achieving 92.1% and 103.86% inhibition at 10 µM, respectively. Additionally, it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 4.18% at 10 µM and shows minimal inhibition (5.236%) of SARS-CoV-2 3CL-Pro protease at 20 µM. In VERO-6 cells, its effect on SARS-CoV-2 induced cytotoxicity was negligible (-0.03%) after 48 hours..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Oxyphencyclimine Hydrochloride (Ulcociclinina) is a synthetic tertiary amine and antimuscarinic agent with antispasmodic and antisecretory activities. |
| Synonyms | Ulcociclinina, Spazamin, Daricon |
| Molecular Weight | 380.91 |
| Formula | C20H29ClN2O3 |
| Cas No. | 125-52-0 |
| Smiles | Cl.CN1CCCN=C1COC(=O)C(O)(C1CCCCC1)c1ccccc1 |
| Relative Density. | 1.18 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | H2O: 6.61 mg/L, Sonication is recommended. DMSO: 3.81 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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