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PSTi8

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Catalog No. T81359 Copy Product Info
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PSTi8 is a synthetic peptide inhibitor of pancreastatin, designed to counteract its anti-insulin effects on glucose and lipid metabolism. It enhances insulin sensitivity by activating AKT/GSK-3β and PKCλ/ζ/SREBP1c pathways in the liver, leading to a 50% reduction in gluconeogenesis and a marked increase in glycogenesis and glycolysis. In adipose and skeletal muscle tissue, PSTi8 suppresses obesity-driven inflammation via the MAPK/NOX3-JNK pathway, boosting GLUT4 translocation and glucose uptake by up to 2-fold. This compound is widely used in preclinical research to investigate metabolic disorders involving insulin resistance, hepatic steatosis, and ER stress.
PSTi8
Cas No. 2434805-63-5
Pack SizePriceEUR StockGlobal StockQuantity
5 mgInquiryInquiryInquiry
50 mgInquiryInquiryInquiry
For In stock only · Estimated delivery: EUR Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Information

Bioactivity
Description
PSTi8 is a synthetic peptide inhibitor of pancreastatin, designed to counteract its anti-insulin effects on glucose and lipid metabolism. It enhances insulin sensitivity by activating AKT/GSK-3β and PKCλ/ζ/SREBP1c pathways in the liver, leading to a 50% reduction in gluconeogenesis and a marked increase in glycogenesis and glycolysis. In adipose and skeletal muscle tissue, PSTi8 suppresses obesity-driven inflammation via the MAPK/NOX3-JNK pathway, boosting GLUT4 translocation and glucose uptake by up to 2-fold. This compound is widely used in preclinical research to investigate metabolic disorders involving insulin resistance, hepatic steatosis, and ER stress.
Chemical Properties
Molecular Weight2427.51
FormulaC98H155N29O41S
Cas No.2434805-63-5
Smiles[C@@H](CC1=CN=CN1)(NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(CNC([C@@H](NC(=O)[C@@H]2CCCN2)CCC(O)=O)=O)=O)CCCCN)=O)=O)CCC(O)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@H](C)C)C(N)=O)=O)C)=O)CCSC)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCCCN)=O)CCC(N)=O)=O)CCC(N)=O)=O)CO)=O
SequencePro-Glu-Gly-Lys-Gly-Glu-Gln-Glu-His-Ser-Gln-Gln-Lys-Glu-Glu-Glu-Glu-Glu-Met-Ala-Val-NH₂
Sequence ShortPEGKGEQEHSQQKEEEEEMAV
Storage & Solubility Information
StorageKeep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 µL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
µL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Please see Product Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: PSTi8 chemical structure | PSTi8 formula | PSTi8 molecular weight
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