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Erinacine A

Name: Erinacine A
Brand: TargetMol
SKU: TN7240
Rating: 4.5 (1 reviews)

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Catalog No. TN7240Cas No. 156101-08-5

Alias (+)-Erinacin A

Erinacine A ((+)-Erinacin A) is a cyanoalkane diterpene extracted from Monkey Head Fungus, a neuroprotective agent with anticancer activity. (+)-Erinacin A induces apoptosis, reduced proliferation, invasiveness, oxidative stress production and cell cycle arrest in cancer cells.

Erinacine A

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Purity: 99.82%

Catalog No. TN7240Alias (+)-Erinacin ACas No. 156101-08-5

Pack Size	Price	Availability	Quantity
1 mg	$1,000	7-10 days

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Purity:99.82%

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COA HPLC

Product Introduction

Bioactivity

Description	Erinacine A ((+)-Erinacin A) is a cyanoalkane diterpene extracted from Monkey Head Fungus, a neuroprotective agent with anticancer activity. (+)-Erinacin A induces apoptosis, reduced proliferation, invasiveness, oxidative stress production and cell cycle arrest in cancer cells.
In vitro	30 μM Erinacine A, treated for 3-24 hours, activated exogenous and endogenous apoptosis (apoptotic) pathways in DLD-1 cells, while down-regulating the expression levels of anti-apoptotic proteins. [1]
In vivo	In a SAM rat model of transient stroke, single-dose intraperitoneal injections of Erinacine A (1, 5, and 10 mg/kg) reduced neuronal cell death and inhibited the expression of inflammatory cytokines in brain tissue. [1] Erinacine A (1, 2, and 5 mg/kg, intraperitoneal injection once daily for 5 days) significantly inhibited tumor growth in a DLD-1 xenograft mouse model, resulting in a significant reduction in tumor size. [2]
Synonyms	(+)-Erinacin A

Chemical Properties

Molecular Weight	432.55
Formula	C₂₅H₃₆O₆
Cas No.	156101-08-5
Smiles	C[C@]12C(C=3[C@](C)([C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)CO4)CC(C=O)=CC3)CC1)=C(C(C)C)CC2
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 8 mg/mL (18.49 mM), Sonication is recommended.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.3119 mL	11.5594 mL	23.1187 mL	115.5936 mL
5 mM	0.4624 mL	2.3119 mL	4.6237 mL	23.1187 mL
10 mM	0.2312 mL	1.1559 mL	2.3119 mL	11.5594 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc