Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 μg | 35 days | $ 183.00 | |
1 mg | 35 days | $ 296.00 | |
5 mg | 35 days | $ 543.00 |
Description | Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM. |
Molecular Weight | 490.84 |
Formula | C23H15ClF4N4O2 |
CAS No. | 330796-24-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 10 mg/mL
DMF: 30 mg/mL
DMF:PBS(pH7.2) (1:2): 0.3 mg/mL
DMSO: 25 mg/mL
You can also refer to dose conversion for different animals. More
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Hedgehog Antagonist VIII 330796-24-2 inhibitor inhibit