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9-(β-D-Xylofuranosyl)adenine

Name: 9-(β-D-Xylofuranosyl)adenine
Brand: TargetMol
SKU: TNU0266
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TNU0266Cas No. 524-69-6

Alias Xylosyladenine, Adenine xyloside

9-(β-D-Xylofuranosyl)adenine (Adenine xyloside) is an adenine nucleoside analog that is a potential smooth muscle vasodilator.9-(β-D-Xylofuranosyl)adenine has anticancer activity.

9-(β-D-Xylofuranosyl)adenine

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Purity: 99.97%

Catalog No. TNU0266Alias Xylosyladenine, Adenine xylosideCas No. 524-69-6

9-(β-D-Xylofuranosyl)adenine (Adenine xyloside) is an adenine nucleoside analog that is a potential smooth muscle vasodilator.9-(β-D-Xylofuranosyl)adenine has anticancer activity.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$46	In Stock	In Stock
25 mg	$76	In Stock	In Stock
50 mg	$113	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.97%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

9-(β-D-Xylofuranosyl)adenine AI Summary

9-(β-D-Xylofuranosyl)adenine exhibits a diverse range of bioactivities. It shows concentration-dependent alteration of cell morphology in various cell lines, including PRK, HeLa, Vero B, and Wi-38, and it significantly reduces growth and inhibits DNA, RNA, and protein synthesis in primary rabbit kidney cells, with an ID50 of 23.0 µg/ml. Additionally, it suppresses the proliferation of mouse myeloma SP2 cells in a concentration-dependent manner. The compound displays notable antiviral activity against numerous viruses such as Herpes simplex, vaccinia, vesicular stomatitis, polio, Coxsackie, parainfluenza, Reo, Sindbis, and forest viruses. In biochemical assays, 9-(β-D-Xylofuranosyl)adenine has demonstrated a potency of 3981.1 nM in inhibiting the proliferation of Plasmodium falciparum, 15848.9 nM and 25118.9 nM in inhibiting Tau fibril formation (using Thioflavin T binding and fluorescence polarization respectively), 22.4 nM as an inhibitor of Histone Lysine Methyltransferase G9a, and 22.4 nM as an inhibitor of human hERG channel activity. Additionally, it has a potency of 794.3 nM in preventing Marburg Virus binding or entry into cells. The compound has also been evaluated for its chemical stability, showing a drug metabolism rate constant of 0.29 x 10^-3 L/mol/min in an acid-catalyzed hydrolysis assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	9-(β-D-Xylofuranosyl)adenine (Adenine xyloside) is an adenine nucleoside analog that is a potential smooth muscle vasodilator.9-(β-D-Xylofuranosyl)adenine has anticancer activity.
Synonyms	Xylosyladenine, Adenine xyloside

Chemical Properties

Molecular Weight	267.24
Formula	C₁₀H₁₃N₅O₄
Cas No.	524-69-6
Smiles	O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CO)[C@@H]1O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (187.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7420 mL	18.7098 mL	37.4195 mL	187.0977 mL
5 mM	0.7484 mL	3.7420 mL	7.4839 mL	37.4195 mL
10 mM	0.3742 mL	1.8710 mL	3.7420 mL	18.7098 mL
20 mM	0.1871 mL	0.9355 mL	1.8710 mL	9.3549 mL
50 mM	0.0748 mL	0.3742 mL	0.7484 mL	3.7420 mL
100 mM	0.0374 mL	0.1871 mL	0.3742 mL	1.8710 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc