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4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid
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Catalog No. TYD-02007Cas No. 124243-00-1
Alias Bis-sulfone Acid
4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Bis-sulfone Acid) is a strong covalent linker containing a free carboxylic acid and two tosyl groups. 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid permits sequential displacement of each tosyl group by thiol or amine nucleophiles through Michael addition. 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid enables covalent “stapling” of two reduced cysteine residues on a protein to restore disulfide bridges, while the free carboxylic acid can be transformed into amides or esters, making the molecule a versatile tool for protein engineering and bioconjugation.
4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid
😃Good
Purity: 98%
Catalog No. TYD-02007Alias Bis-sulfone AcidCas No. 124243-00-1
4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Bis-sulfone Acid) is a strong covalent linker containing a free carboxylic acid and two tosyl groups. 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid permits sequential displacement of each tosyl group by thiol or amine nucleophiles through Michael addition. 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid enables covalent “stapling” of two reduced cysteine residues on a protein to restore disulfide bridges, while the free carboxylic acid can be transformed into amides or esters, making the molecule a versatile tool for protein engineering and bioconjugation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $30 | - | In Stock | |
| 25 mg | $53 | - | In Stock | |
| 50 mg | $80 | - | In Stock | |
| 100 mg | $118 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Bis-sulfone Acid) is a strong covalent linker containing a free carboxylic acid and two tosyl groups. 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid permits sequential displacement of each tosyl group by thiol or amine nucleophiles through Michael addition. 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid enables covalent “stapling” of two reduced cysteine residues on a protein to restore disulfide bridges, while the free carboxylic acid can be transformed into amides or esters, making the molecule a versatile tool for protein engineering and bioconjugation. |
| Synonyms | Bis-sulfone Acid |
| Molecular Weight | 500.58 |
| Formula | C25H24O7S2 |
| Cas No. | 124243-00-1 |
| Smiles | O=C(O)C1=CC=C(C=C1)C(=O)C(CS(=O)(=O)C2=CC=C(C=C2)C)CS(=O)(=O)C3=CC=C(C=C3)C |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (159.81 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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