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(-)-Irofulven (Synonyms: NSC683863, NSC 683863, MGI-114, MGI114, MGI 114, 6-Hydroxymethylacylfulvene)

Name: (-)-Irofulven
Brand: TargetMol
SKU: T24176
Rating: 4.5 (1 reviews)

Catalog No. T24176 Copy Product Info

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(-)-Irofulven is an agent of DNA-damaging and antitumor. (-)-Irofulven is used for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.

(-)-Irofulven

Copy Product Info

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Catalog No. T24176

Synonyms NSC683863, NSC 683863, MGI-114, MGI114, MGI 114, 6-Hydroxymethylacylfulvene

(-)-Irofulven is an agent of DNA-damaging and antitumor. (-)-Irofulven is used for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.

Cas No. 158440-71-2

Pack Size	Price	USA Stock	Global Stock
25 mg	Inquiry	3-6 months	3-6 months
50 mg	Inquiry	3-6 months	3-6 months
100 mg	Inquiry	3-6 months	3-6 months

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Appearance:Liquid

Color:Transparent

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COA

Product Introduction

Bioactivity

Description	(-)-Irofulven is an agent of DNA-damaging and antitumor. (-)-Irofulven is used for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.
Synonyms	NSC683863, NSC 683863, MGI-114, MGI114, MGI 114, 6-Hydroxymethylacylfulvene

Chemical Properties

Molecular Weight	246.3
Formula	C₁₅H₁₈O₃
Cas No.	158440-71-2
Smiles	CC=1C2([C@@](C)(O)C(=O)C=3C1C(CO)=C(C)C3)CC2
Relative Density.	1.28g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50.00 mg/mL (203.00 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0601 mL	20.3004 mL	40.6009 mL	203.0045 mL
5 mM	0.8120 mL	4.0601 mL	8.1202 mL	40.6009 mL
10 mM	0.4060 mL	2.0300 mL	4.0601 mL	20.3004 mL
20 mM	0.2030 mL	1.0150 mL	2.0300 mL	10.1502 mL
50 mM	0.0812 mL	0.4060 mL	0.8120 mL	4.0601 mL
100 mM	0.0406 mL	0.2030 mL	0.4060 mL	2.0300 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc