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N-(α-Linolenoyl) Tyrosine

Name: N-(α-Linolenoyl) Tyrosine
Brand: TargetMol
SKU: T38222
Rating: 4.5 (1 reviews)

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Catalog No. T38222Cas No. 259143-19-6

Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier. In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson's therapeutic agent.

N-(α-Linolenoyl) Tyrosine

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Catalog No. T38222Cas No. 259143-19-6

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$258	35 days	35 days
10 mg	$482	35 days	35 days
50 mg	$1,960	35 days	35 days
100 mg	$3,500	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	441.6
Formula	C₂₇H₃₉NO₄
Cas No.	259143-19-6
Smiles	C([C@H](NC(CCCCCCC/C=C\C/C=C\C/C=C\CC)=O)C(O)=O)C1=CC=C(O)C=C1
Relative Density.	no data available
Sequence	{α-Linolenoyl}-Tyr
Sequence Short	{α-Linolenoyl}-Y

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 30 mg/mL (67.93 mM), Sonication is recommended.

PBS (pH 7.2): 1 mg/mL (2.26 mM), Sonication is recommended.

Ethanol: 30 mg/mL (67.93 mM), Sonication is recommended.

DMSO: 30 mg/mL (67.93 mM), Sonication is recommended.

Solution Preparation Table

PBS (pH 7.2)/DMF/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2645 mL	11.3225 mL	22.6449 mL	113.2246 mL

DMF/Ethanol/DMSO

	1mg	5mg	10mg	50mg
5 mM	0.4529 mL	2.2645 mL	4.5290 mL	22.6449 mL
10 mM	0.2264 mL	1.1322 mL	2.2645 mL	11.3225 mL
20 mM	0.1132 mL	0.5661 mL	1.1322 mL	5.6612 mL
50 mM	0.0453 mL	0.2264 mL	0.4529 mL	2.2645 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc