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Acetoacetic acid (3-oxobutanoic acid) is a β-keto acid and oxidative stress inducer, produced in the body when poor hepatic metabolism leads to excessive catabolism of fatty acids, is involved in the process of gluconeogenesis, and can be used as an indicator of in ketoacidosis.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $40 | - | In Stock | |
| 5 mg | $98 | In Stock | In Stock | |
| 10 mg | $147 | - | In Stock | |
| 25 mg | $255 | - | In Stock | |
| 50 mg | $378 | - | In Stock | |
| 100 mg | $559 | - | In Stock |
| Description | Acetoacetic acid (3-oxobutanoic acid) is a β-keto acid and oxidative stress inducer, produced in the body when poor hepatic metabolism leads to excessive catabolism of fatty acids, is involved in the process of gluconeogenesis, and can be used as an indicator of in ketoacidosis. |
| In vitro | Methods: Acetoacetic acid (0.6, 2.4, 4.8 mM, 24 h) was used to treat dairy cow hepatocytes, and the related enzyme activities and protein expressions were determined. Results: Acetoacetic acid can reduce the mRNA expression and enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in a dose-dependent manner, increase the malondialdehyde (MDA) content, induce oxidative stress, and downregulate the mRNA expression of apolipoprotein B100 (ApoB100), apolipoprotein E (ApoE), and low-density lipoprotein receptor (LDLR), inhibit the assembly of very low-density lipoprotein (VLDL), and lead to the accumulation of intracellular triglycerides (TG) and the reduction of VLDL content in the culture medium. [1] |
| Synonyms | 3-oxobutanoic acid |
| Molecular Weight | 102.09 |
| Formula | C4H6O3 |
| Cas No. | 541-50-4 |
| Smiles | O=C(O)CC(=O)C |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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