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4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $413 | Inquiry | Inquiry |
| Description | 4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol. |
| In vitro | 4-Methoxy-17-estradiol treatment significantly decreased cell growth and increased mitotic index. Elevation of ROS and SOD activity, with a concomitant decrease in the intracellular GSH/GSSG ratio, was also detected in 4-Methoxy-17-estradiol-treated cells. Quantitative comet assay showed increased oxidative DNA damage in the 4-Methoxy-17-estradiol-treated H1355 cells, which could be significantly reduced by the anti-oxidant N-acetylcysteine (NAC)[1]. |
| In vivo | 4-Methoxy-17-estradiol had much weaker estrogenic activity and have similar lipid-modulating effects compared to 4-hydroxyestradiol in ovariectomized female rats[3]. |
| Molecular Weight | 302.41 |
| Formula | C19H26O3 |
| Cas No. | 26788-23-8 |
| Smiles | C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1c(cc1)c3c(OC)c1O)[C@H]2O |
| Relative Density. | 1.178 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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