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Taprenepag isopropyl

Name: Taprenepag isopropyl
Brand: TargetMol
SKU: T16988
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16988Cas No. 1005549-94-9

Alias PF-04217329, PF04217329

Taprenepag isopropyl (PF-04217329) is a selective EP2 agonist and prodrug of CP-544326. Following ocular administration, it induces elevated cAMP levels and reduced intraocular pressure, rendering it suitable for treating glaucoma.

Taprenepag isopropyl

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Purity: 99.44%

Catalog No. T16988Alias PF-04217329, PF04217329Cas No. 1005549-94-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$42	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.44%

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COA

Product Introduction

Bioactivity

Description	Taprenepag isopropyl (PF-04217329) is a selective EP2 agonist and prodrug of CP-544326. Following ocular administration, it induces elevated cAMP levels and reduced intraocular pressure, rendering it suitable for treating glaucoma.
In vivo	Taprenepag isopropyl (0.75, 12, or 36 μg/day, instilled into the right eye twice daily for 28 days) demonstrated intraocular pressure-lowering effects in cynomolgus monkeys but also induced adverse reactions such as iritis, photophobia, and increased corneal thickness. These adverse reactions were reversible after discontinuation of the drug [1].
Synonyms	PF-04217329, PF04217329

Chemical Properties

Molecular Weight	520.6
Formula	C₂₇H₂₈N₄O₅S
Cas No.	1005549-94-9
Smiles	CC(C)OC(=O)COc1cccc(CN(Cc2ccc(cc2)-n2cccn2)S(=O)(=O)c2cccnc2)c1
Relative Density.	1.26 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (307.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (9.6 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9209 mL	9.6043 mL	19.2086 mL	96.0430 mL
5 mM	0.3842 mL	1.9209 mL	3.8417 mL	19.2086 mL
10 mM	0.1921 mL	0.9604 mL	1.9209 mL	9.6043 mL
20 mM	0.0960 mL	0.4802 mL	0.9604 mL	4.8022 mL
50 mM	0.0384 mL	0.1921 mL	0.3842 mL	1.9209 mL
100 mM	0.0192 mL	0.0960 mL	0.1921 mL	0.9604 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc