Signal-Regulatory Protein Gamma (SIRPG) is a member of the signal-regulatory protein (SIRP) family and also belongs to the immunoglobulin superfamily. SIRPG is detected in the liver, and at very low levels in the brain, heart, lung, pancreas, kidney, placenta, and skeletal muscle. SIRPG is an immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG as receptor-type transmembrane glycoproteins is involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | 5 days | $ 116.00 | |
50 μg | 5 days | $ 310.00 | |
500 μg | 5 days | $ 1,900.00 | |
1 mg | 5 days | $ 2,730.00 |
Description | Signal-Regulatory Protein Gamma (SIRPG) is a member of the signal-regulatory protein (SIRP) family and also belongs to the immunoglobulin superfamily. SIRPG is detected in the liver, and at very low levels in the brain, heart, lung, pancreas, kidney, placenta, and skeletal muscle. SIRPG is an immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG as receptor-type transmembrane glycoproteins is involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. |
Species | Human |
Expression System | HEK293 Cells |
Tag | C-hFc |
Accession Number | Q9P1W8 |
Synonyms | SIRP-Gamma, SIRP-β-2, SIRP-Beta-2, Signal-Regulatory Protein Gamma, CD172 Antigen-Like Family Member B, SIRPB2, Signal-Fegulatory Protein β-2, SIRP-γ, SIRPG, SIRP-b2, Signal-Regulatory Protein γ, CD172g, Signal-Fegulatory Protein Beta-2 |
Amino Acid | Glu29-Pro360 |
Construction | Glu29-Pro360 |
Protein Purity | Greater than 90% as determined by reducing SDS-PAGE. (QC verified) |
Molecular Weight | 80 KDa (reducing condition) |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Signal-Regulatory Protein Gamma (SIRPG) is a member of the signal-regulatory protein (SIRP) family and also belongs to the immunoglobulin superfamily. SIRPG is detected in the liver, and at very low levels in the brain, heart, lung, pancreas, kidney, placenta, and skeletal muscle. SIRPG is an immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG as receptor-type transmembrane glycoproteins is involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. |
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Please read the User Guide of Recombinant Proteins for more specific information.
SIRP gamma Protein, Human, Recombinant (hFc) SIRP-Gamma SIRP-β-2 SIRP-Beta-2 Signal-Regulatory Protein Gamma CD172 Antigen-Like Family Member B SIRPB2 SIRP-b-2 Signal-Fegulatory Protein β-2 SIRP-γ SIRPB 2 SIRPG SIRP-b2 Signal-Regulatory Protein γ Signal-Fegulatory Protein b-2 CD172g SIRPB-2 Signal-Fegulatory Protein Beta-2 recombinant recombinant-proteins proteins protein