Shopping Cart

Your shopping cart is currently empty

Mianserin hydrochloride

Name: Mianserin hydrochloride
Brand: TargetMol
SKU: T0783
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T0783Cas No. 21535-47-7

Alias ORG GB-94 HCl, Mianserin HCl

Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant properties that blocks alpha-adrenergic, histamine H1, and certain serotonin receptors; it may cause drowsiness and hematological issues.

Mianserin hydrochloride

Copy Product Info

🥰Excellent

Purity: 99.82%

Catalog No. T0783Alias ORG GB-94 HCl, Mianserin HClCas No. 21535-47-7

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$35	In Stock	In Stock
500 mg	$108	In Stock	In Stock
1 g	$159	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.82%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant properties that blocks alpha-adrenergic, histamine H1, and certain serotonin receptors; it may cause drowsiness and hematological issues.
In vitro	Mianserin dose-dependently elevates extracellular norepinephrine levels in the prefrontal cortex with minimal impact on the reuptake of norepinephrine in the rat cerebral cortex, due to its blockade of presynaptic inhibitory α2-adrenergic receptors and induction of regeneration-mediated release enhancement. In neonatal 6-OHDA-lesioned rats, mianserin attenuates the effects of SKF38393 and M-CPP, indicating that the actions of dopamine receptor agonists are mediated through the 5-HT neurochemical system. Additionally, in the medial prefrontal cortex of neonatal 6-OHDA-lesioned rats, 10 mg/kg S.C. Mianserin increased extracellular dopamine approximately 6-fold.
In vivo	In elevated plus-maze experiments, Eltoprazine and Mianserin exhibit opposite effects: Eltoprazine induces anxiogenic-like behavior, while Mianserin triggers an anxiolytic-like response. Mianserin leads to a decreased number of these sites, whereas Eltoprazine results in an increase. Additionally, a subcutaneous dose of 2 mg/kg Mianserin produces a significant statistical increase in dopamine levels, exceeding 30% when compared to saline.
Synonyms	ORG GB-94 HCl, Mianserin HCl

Chemical Properties

Molecular Weight	300.83
Formula	C₁₈H₂₁ClN₂
Cas No.	21535-47-7
Smiles	Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21
Relative Density.	1.18 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 99.7 mM, Sonication is recommended.

DMSO: 4.23 mg/mL (14.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.3241 mL	16.6207 mL	33.2414 mL	166.2068 mL
5 mM	0.6648 mL	3.3241 mL	6.6483 mL	33.2414 mL
10 mM	0.3324 mL	1.6621 mL	3.3241 mL	16.6207 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1662 mL	0.8310 mL	1.6621 mL	8.3103 mL
50 mM	0.0665 mL	0.3324 mL	0.6648 mL	3.3241 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc