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Antitumor agent-23

Catalog No. T39889 CAS 2355185-12-3

Antitumor agent-23 exhibits potent antitumoral activity, as demonstrated by its GI50 values of 38, 48, 5, 27, 80, and 28 nM against the lymphoma cell lines GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI respectively.

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Antitumor agent-23, CAS 2355185-12-3

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25 mg	Inquiry	$ 1,520.00

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Description

In vitro

Antitumor agent-23, ranging from 0.001 to 100 μM over five days, effectively inhibits the proliferation of various lymphoma cell lines[1]. In HPV-positive cervical cancer cells, concentrations between 2 and 70 nM over 72 hours significantly upregulate p53 protein levels and induce acetylation at lysine 382 of p53 (K382Ac-p53)[1]. Detailed Cell Proliferation Assay findings reveal GI50 values of 38, 48, 5, 27, 80, and 28 nM for GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI cell lines, respectively, over a five-day period[1]. Western Blot Analysis conducted on the HPV16-positive cervical cancer cell line (CaSki) demonstrated noticeable p53 protein expression enhancement starting at 7 nM and noticeable acetylation at p53 lysine 382 starting at 20 nM over a 72-hour incubation period[1].

Molecular Weight	506.732
Formula	C28H50N4O4
CAS No.	2355185-12-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Marc Labelle, et al. 1 -(piperidinocarbonylmethyl)-2-oxopiperazine derivatives for treating cancer. WO2019118973A1.

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Keywords

Antitumor agent-23 2355185-12-3 Antitumor agent23 Antitumor agent 23 inhibitor inhibit

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