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Antitumor agent-23
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Catalog No. T39889Cas No. 2355185-12-3
Antitumor agent-23 exhibits potent antitumoral activity, as demonstrated by its GI50 values of 38, 48, 5, 27, 80, and 28 nM against the lymphoma cell lines GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI respectively.
Antitumor agent-23
Copy Product Info😃Good
Catalog No. T39889Cas No. 2355185-12-3
Antitumor agent-23 exhibits potent antitumoral activity, as demonstrated by its GI50 values of 38, 48, 5, 27, 80, and 28 nM against the lymphoma cell lines GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI respectively.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Antitumor agent-23 exhibits potent antitumoral activity, as demonstrated by its GI50 values of 38, 48, 5, 27, 80, and 28 nM against the lymphoma cell lines GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI respectively. |
| In vitro | Antitumor agent-23, ranging from 0.001 to 100 μM over five days, effectively inhibits the proliferation of various lymphoma cell lines[1]. In HPV-positive cervical cancer cells, concentrations between 2 and 70 nM over 72 hours significantly upregulate p53 protein levels and induce acetylation at lysine 382 of p53 (K382Ac-p53)[1]. Detailed Cell Proliferation Assay findings reveal GI50 values of 38, 48, 5, 27, 80, and 28 nM for GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI cell lines, respectively, over a five-day period[1]. Western Blot Analysis conducted on the HPV16-positive cervical cancer cell line (CaSki) demonstrated noticeable p53 protein expression enhancement starting at 7 nM and noticeable acetylation at p53 lysine 382 starting at 20 nM over a 72-hour incubation period[1]. |
| Molecular Weight | 506.72 |
| Formula | C28H50N4O4 |
| Cas No. | 2355185-12-3 |
| Smiles | CC(C)C[C@H](N1CCN[C@@H](CC(C)C)C1=O)C(=O)N1CC[C@@]2(C[C@@H]1C)OC[C@H](CN1CCCC1)CO2 |
| Relative Density. | 1.13 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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