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trans-Urocanic Acid

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Catalog No. T37547Cas No. 3465-72-3

Alias trans-UCA, (E)-Urocanic acid

trans-Urocanic Acid ((E)-Urocanic acid), a compound predominantly distributed in the hippocampus and prefrontal cortex, is an isomer of cis-UCA, an epidermal UV-protectant, which enhances the stability of tenofovir eplerenomide in long-acting HIV applications. trans-Urocanic acid potently modulates immune trans-urocanic acid effectively modulates immune function, inhibits human natural killer cell activity in vitro, and can be used in Alzheimer's disease research.

trans-Urocanic Acid

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Purity: 99.82%

Catalog No. T37547Alias trans-UCA, (E)-Urocanic acidCas No. 3465-72-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	trans-Urocanic Acid ((E)-Urocanic acid), a compound predominantly distributed in the hippocampus and prefrontal cortex, is an isomer of cis-UCA, an epidermal UV-protectant, which enhances the stability of tenofovir eplerenomide in long-acting HIV applications. trans-Urocanic acid potently modulates immune trans-urocanic acid effectively modulates immune function, inhibits human natural killer cell activity in vitro, and can be used in Alzheimer's disease research.
In vitro	In primary human keratinocytes, trans-Urocanic acid (100 μg/mL; 24 hours) reduces cell proliferation and viability[2].
Synonyms	trans-UCA, (E)-Urocanic acid

Chemical Properties

Molecular Weight	138.12
Formula	C₆H₆N₂O₂
Cas No.	3465-72-3
Smiles	C(=C/C(O)=O)\C1=CN=CN1
Relative Density.	1.430 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

PBS (pH 7.2): 0.3 mg/mL (2.17 mM), Sonication is recommended.

DMSO: 15 mg/mL (108.6 mM), Sonication is recommended.

DMF: 3 mg/mL (21.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

PBS (pH 7.2)/DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	7.2401 mL	36.2004 mL	72.4008 mL	362.0041 mL

DMF/DMSO

	1mg	5mg	10mg	50mg
5 mM	1.4480 mL	7.2401 mL	14.4802 mL	72.4008 mL
10 mM	0.7240 mL	3.6200 mL	7.2401 mL	36.2004 mL
20 mM	0.3620 mL	1.8100 mL	3.6200 mL	18.1002 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.1448 mL	0.7240 mL	1.4480 mL	7.2401 mL
100 mM	0.0724 mL	0.3620 mL	0.7240 mL	3.6200 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc