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trans-Urocanic Acid

Catalog No. T37547 CAS 3465-72-3

trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine. It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis. Upon UVB exposure, trans-urocanic acid is converted to the cis isomer, which is known to activate regulatory T cells.

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trans-Urocanic Acid, CAS 3465-72-3

Pack Size	Availability	Price/USD	Quantity
1 g	35 days	$ 93.00
5 g	35 days	$ 335.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	138.12
Formula	C6H6N2O2
CAS No.	3465-72-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

PBS (pH 7.2): 0.3 mg/mL

DMSO: 15 mg/mL

DMF: 3 mg/mL

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

trans-Urocanic Acid 3465-72-3 transUrocanic Acid trans Urocanic Acid inhibitor inhibit

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