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Cyclic-di-GMP disodium

Catalog No. T36983 CAS 2222132-40-1

Synonyms: Cyclic diguanylate, 5GP-5GP disodium, 3',5'-Cyclic diguanylic acid, Cyclic di-GMP (sodium salt), cyclic diguanylate disodium, c-di-GMP, c-di-GMP disodium

Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, and cell cycle progression.Cyclic-di-GMP disodium displays antiproliferative activity against cancer cells, inducing elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Cyclic-di-GMP disodium Chemical Structure

Cyclic-di-GMP disodium, CAS 2222132-40-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 172.00
5 mg	In stock	$ 438.00
10 mg	In stock	$ 647.00
25 mg	In stock	$ 987.00
50 mg	In stock	Inquiry

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Purity: 99.93%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, and cell cycle progression.Cyclic-di-GMP disodium displays antiproliferative activity against cancer cells, inducing elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research cancer.
In vitro	Cyclic-di-GMP disodium (0.5-50 μM; 5 days) demonstrates inhibition of human colon cancer cell proliferation.[1] Cyclic-di-GMP disodium (0.5-50 μM; 5 days) induces a targeted increase in CD4 expression within Jurkat cells and triggers S-phase cell cycle arrest in the same cells.[2]
In vivo	Cyclic-di-GMP disodium (100 μg/per; i.v.; two sequential vaccinations 9 days apart) augments TriVax-induced immune responses against melanoma in mice and further amplifies the anti-tumor effects of TriVax.[3]

Synonyms	Cyclic diguanylate, 5GP-5GP disodium, 3',5'-Cyclic diguanylic acid, Cyclic di-GMP (sodium salt), cyclic diguanylate disodium, c-di-GMP, c-di-GMP disodium
Molecular Weight	736.39
Formula	C20H24N10Na2O14P2
CAS No.	2222132-40-1

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 144.0 mg/mL (196.1 mM), Sonication is recommended.

References and Literature

1. Karaolis DK, et al. 3',5'-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation. Biochem Biophys Res Commun. 2005;329(1):40-45. 2. Steinberger O, et al. Elevated expression of the CD4 receptor and cell cycle arrest are induced in Jurkat cells by treatment with the novel cyclic dinucleotide 3',5'-cyclic diguanylic acid. FEBS Lett. 1999;444(1):125-129. 3. Wang Z, et al. STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice. Cancer Immunol Immunother. 2015;64(8):1057-1066. 4. Jenal U, et al. Cyclic di-GMP: second messenger extraordinaire. Nat Rev Microbiol. 2017;15(5):271-284.

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Keywords

Cyclic-di-GMP disodium 2222132-40-1 Immunology/Inflammation Metabolism Endogenous Metabolite STING Cyclic diguanylate 5GP-5GP disodium 3',5'-Cyclic diguanylic acid Cyclic di-GMP (sodium salt) cyclic diguanylate disodium Cyclic-di-GMP c-di-GMP 5GP-5GP Cyclic di-GMP c-di-GMP disodium inhibitor inhibit

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