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Mespirenone
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Catalog No. T71664Cas No. 87952-98-5
Mespirenone is a spironolactone derivative and aldosterone antagonist with diuretic effects.
Mespirenone
Copy Product Info🥰Excellent
Purity: 99.18%
Catalog No. T71664Cas No. 87952-98-5
Mespirenone is a spironolactone derivative and aldosterone antagonist with diuretic effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | In Stock | In Stock | |
| 5 mg | $483 | In Stock | In Stock | |
| 10 mg | $692 | In Stock | In Stock | |
| 25 mg | $1,080 | In Stock | In Stock | |
| 50 mg | $1,490 | In Stock | In Stock | |
| 100 mg | $1,970 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.18%
Appearance:Solid
Color:Yellow
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Product Introduction
Mespirenone AI Summary
Mespirenone exhibits antialdosterone activity in rats, with a relative potency compared to Spironolactone. It demonstrates significant bioactivity in displacing [3H]aldosterone from the mineralocorticoid receptor of rabbit kidney with an RBA of 21.0%, while showing minimal activity against the glucocorticoid receptor with an RBA of less than 0.1%. Additionally, Mespirenone displays antiandrogenic effects, influencing the weight of seminal vesicles and prostate in rats following subcutaneous and oral administrations at various doses. It also exhibits progestational activity in rabbits, as indicated by the McPhail index, and inhibits ovulation following oral doses. Furthermore, the compound exerts activity in inhibiting aldosterone synthase in rat adrenal glands, resulting in a reduction of aldosterone and 18-OH-corticosterone levels at a 100 µM concentration with an inhibition rate exceeding 40.0%. Mespirenone shows differential binding affinities to androgen and progesterone receptors, highlighting its multifaceted hormonal activity profile..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Mespirenone is a spironolactone derivative and aldosterone antagonist with diuretic effects. |
| Molecular Weight | 426.57 |
| Formula | C25H30O4S |
| Cas No. | 87952-98-5 |
| Smiles | C[C@@]12[C@]3([C@@]4([C@@](C4)([C@]1([C@]5([C@](CC2)([C@]6(C)C(C[C@H]5SC(C)=O)=CC(=O)C=C6)[H])[H])[H])[H])[H])OC(=O)CC3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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