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4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. By inhibiting PARP1, 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activating the caspase-3/GSDME pathway, which leads to tumor cell apoptosis (apoptosis) and pyroptosis (pyroptosis). It exhibits antitumor activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | 4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. By inhibiting PARP1, 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activating the caspase-3/GSDME pathway, which leads to tumor cell apoptosis (apoptosis) and pyroptosis (pyroptosis). It exhibits antitumor activity. |
Molecular Weight | 638.572 |
Formula | C32H30O14 |
Cas No. | 2265910-52-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. |
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