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coagulation factor II (thrombin) B chain fragment [Homo sapiens]

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Catalog No. TP2234

Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin. Thrombin is also active in the catalysis of many other coagulation-related reactions.

coagulation factor II (thrombin) B chain fragment [Homo sapiens]

coagulation factor II (thrombin) B chain fragment [Homo sapiens]

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Catalog No. TP2234
Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin. Thrombin is also active in the catalysis of many other coagulation-related reactions.
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1 mg$50InquiryInquiry
5 mg$143InquiryInquiry
10 mg$235InquiryInquiry
25 mg$329InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin. Thrombin is also active in the catalysis of many other coagulation-related reactions.
In vitro
Thrombin is implicated as a major factor in vasospasm following subarachnoid hemorrhage. Blood from a ruptured cerebral aneurysm clot around a cerebral artery, releasing thrombin. This can induce an acute and prolonged narrowing of the blood vessel, potentially resulting in cerebral ischemia and infarction (stroke). Beyond its key role in the dynamic process of thrombus formation, thrombin has a pronounced pro-inflammatory character, which may influence the onset and progression of atherosclerosis [2][3].
Chemical Properties
Molecular Weight1957.26
FormulaC90H137N23O24S
SmilesN[C@@]([H])(CCCCN)C(=O)N1CCC[C@@]1([H])C(=O)N[C@]([H])(C(=O)N[C@](C)([H])C(=O)N[C@]([H])(C/C2=C/C=CC=C2)C(=O)N[C@]([H])(CO)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@]([H])(C/C3=C/C=C(/O)C=C3)C(=O)N[C@@]([H])(C(=O)N[C@]([H])(C/C4=C/N=CN4)C(=O)N5CCC[C@@]5([H])C(=O)N[C@]([H])(C(=O)N[C@]([H])(C[S])C(=O)N[C@@]([H])(CC(C)(C)[H])C(=O)N6CCC[C@]6([H])C(=O)N[C@]([H])(CC(O)=O)C(=O)N[C@]([H])(CCCNC(N)=N)C(=O)O)C(C)(C)[H])[C@@](C)([H])CC)C(C)(C)[H]
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: ≥195.7 mg/mL, Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

coagulation factor II (thrombin) B chain fragment [Homo sapiens]
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