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NLG802

Name: NLG802
Brand: TargetMol
SKU: T39476
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39476Cas No. 2071683-99-1

NLG802 is a prodrug of indoximod, serving as an orally active inhibitor of indoleamine 2,3-dioxygenase (IDO).

NLG802

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Purity: 99.61%

Catalog No. T39476Cas No. 2071683-99-1

NLG802 is a prodrug of indoximod, serving as an orally active inhibitor of indoleamine 2,3-dioxygenase (IDO).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$37	In Stock	In Stock
5 mg	$59	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$178	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.61%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

NLG802 is a prodrug of indoximod, serving as an orally active inhibitor of indoleamine 2,3-dioxygenase (IDO).

In vitro

NLG802 showed moderate direct (IC50 5 μM) and time dependent (7-fold shift) inhibition of CYP3A4, weak inhibition to CYP2D6 (IC50 19 μM) and CYP2C19 (IC50 47 μM), no inhibition of CYP450 1A2, 2B6, 2C8 and 2C9 (IC50 > 50 μM) and no induction of CYP1A2, 2B6 or 3A4 in human hepatocytes. NLG802 showed moderate inhibition of P-gp transporter activity in MDR1-MDCKII cells (IC50 27 μM), does not inhibit the anion and cation transporters OATP1B1, OATP1B3, OAT1, OAT3, OCT1 and OCT2 in HEK293 cells expressing these transporters (IC50 > 50 μM) or the BRCP transporter in Caco-2 cells[1].

Chemical Properties

Molecular Weight	395.92
Formula	C₂₀H₃₀ClN₃O₃
Cas No.	2071683-99-1
Smiles	Cl.CCOC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H](N)CC(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (568.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5258 mL	12.6288 mL	25.2576 mL	126.2881 mL
5 mM	0.5052 mL	2.5258 mL	5.0515 mL	25.2576 mL
10 mM	0.2526 mL	1.2629 mL	2.5258 mL	12.6288 mL
20 mM	0.1263 mL	0.6314 mL	1.2629 mL	6.3144 mL
50 mM	0.0505 mL	0.2526 mL	0.5052 mL	2.5258 mL
100 mM	0.0253 mL	0.1263 mL	0.2526 mL	1.2629 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc