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Dinoprost tromethamine salt

Name: Dinoprost tromethamine salt
Brand: TargetMol
SKU: T4546
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4546Cas No. 38562-01-5

Alias Zinoprost, Prostin F2 alpha, Prostaglandin F2α THAM, PGF2α THAM, Dinoprost Tromethamine, Dinolytic

Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.

Dinoprost tromethamine salt

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Purity: 99.88%

Catalog No. T4546Alias Zinoprost, Prostin F2 alpha, Prostaglandin F2α THAM, PGF2α THAM, Dinoprost Tromethamine, DinolyticCas No. 38562-01-5

Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$52	In Stock	In Stock
10 mg	$73	In Stock	In Stock
25 mg	$150	In Stock	In Stock
50 mg	$228	In Stock	In Stock
100 mg	$346	-	In Stock
1 mL x 10 mM (in DMSO)	$57	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Dinoprost tromethamine salt AI Summary

Dinoprost tromethamine salt exhibits a diverse range of bioactivities across various targets. It modulates Lamin A splicing with a high potency of 10.0 nM and shows significant inhibitory activity against Lassa Virus binding or entry into cells with a potency of 4.6 nM. It inhibits N370S glucocerebrosidase, potentially aiding chaperone treatment for Gaucher Disease, with a potency of 794.3 nM. Additionally, it shows inhibitory effects on Chronic Active B-Cell Receptor Signaling with potencies of 1032.3 nM and 2909.3 nM in different assays. The compound acts against the Choline Transporter (CHT) with IC50 values of 2944.57 nM and 2771.7 nM, and against the GLP-1 Receptor Inverse Agonists with a potency of 2511.9 nM. It also inhibits Cruzain and HPGD with potencies of 31622.8 nM and 12589.3 nM, respectively. Further, Dinoprost tromethamine salt inhibits the Parathyroid Hormone Receptor (PTHR) with a potency of 15848.9 nM and induces DNA re-replication in SW480 colon adenocarcinoma cells with a potency of 6309.6 nM. The compound exhibits inhibition activity against human MRP4 with an IC50 value of 7100.0 nM and demonstrates antibacterial activity against various strains, including Escherichia coli and Pseudomonas aeruginosa, with varying inhibition levels. It shows antifungal activity against Candida albicans but negative inhibition against Cryptococcus neoformans..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
Synonyms	Zinoprost, Prostin F2 alpha, Prostaglandin F2α THAM, PGF2α THAM, Dinoprost Tromethamine, Dinolytic

Chemical Properties

Molecular Weight	475.62
Formula	C₂₄H₄₅NO₈
Cas No.	38562-01-5
Smiles	NC(CO)(CO)CO.CCCCCC(O)C=CC1C(O)CC(O)C1CC=CCCCC(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 199.7 mM, Sonication is recommended.

DMSO: 199.7 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1025 mL	10.5126 mL	21.0252 mL	105.1259 mL
5 mM	0.4205 mL	2.1025 mL	4.2050 mL	21.0252 mL
10 mM	0.2103 mL	1.0513 mL	2.1025 mL	10.5126 mL
20 mM	0.1051 mL	0.5256 mL	1.0513 mL	5.2563 mL
50 mM	0.0421 mL	0.2103 mL	0.4205 mL	2.1025 mL
100 mM	0.0210 mL	0.1051 mL	0.2103 mL	1.0513 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc