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Linoleoylcarnitine

Name: Linoleoylcarnitine
Brand: TargetMol
SKU: T9338
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9338 Copy Product Info

Purity: 99.78%

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Linoleyl carnitine is an acylcarnitine that can be utilized in studies of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and fatty acid oxidation disorders in fibroblasts. The metabolic relevance of Linoleyl carnitine supports the use of Linoleyl carnitine in investigations of mitochondrial fatty acid oxidation, metabolic disorders, acylcarnitine profiling, and cellular energy metabolism.

Cas No. 36816-10-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$98	-	In Stock
5 mg	$238	-	In Stock
10 mg	$357	-	In Stock
25 mg	$593	-	In Stock
50 mg	$845	-	In Stock
100 mg	$1,130	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.78%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

In vitro

Method: Voltage-clamped Xenopus laevis oocytes expressing GlyT2 were exposed to linoleoyl-L-carnitine at concentrations up to 3 μM in the presence of 30 μM glycine, and glycine-evoked transport currents were recorded.[1]
Rresult: Linoleoyl-L-carnitine was a weak and incomplete GlyT2 inhibitor; 3 μM reduced the response to 30 μM glycine by 9.5±3.2%, substantially less than oleoyl-L-carnitine.[1]
Method: Linoleoylcarnitine, designated C18:2 acylcarnitine, was included in a validated HILIC-MS/MS method for the simultaneous quantification of 13 acylcarnitines in human serum. RPLC and HILIC separation were compared before method validation.[2]
Rresult: HILIC provided suitable separation and quantitative measurement of serum C18:2 acylcarnitine together with the other acylcarnitines, with validated linearity, accuracy, precision and analytical sensitivity.[2]

Chemical Properties

Molecular Weight	423.63
Formula	C₂₅H₄₅NO₄
Cas No.	36816-10-1
Smiles	[C@H](OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)(C[N+](C)(C)C)CC([O-])=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (188.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3606 mL	11.8028 mL	23.6055 mL	118.0275 mL
5 mM	0.4721 mL	2.3606 mL	4.7211 mL	23.6055 mL
10 mM	0.2361 mL	1.1803 mL	2.3606 mL	11.8028 mL
20 mM	0.1180 mL	0.5901 mL	1.1803 mL	5.9014 mL
50 mM	0.0472 mL	0.2361 mL	0.4721 mL	2.3606 mL
100 mM	0.0236 mL	0.1180 mL	0.2361 mL	1.1803 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc