Powder: -20°C for 3 years | In solvent: -80°C for 1 year
20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor, but does not appear to function as an agonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 μg | 35 days | $ 413.00 | |
50 μg | 35 days | $ 778.00 | |
100 μg | 35 days | $ 1,460.00 |
Description | 20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor, but does not appear to function as an agonist. |
Synonyms | 20-hydroxy Leukotriene B4 |
Molecular Weight | 352.471 |
Formula | C20H32O5 |
CAS No. | 79516-82-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: >50 mg/mL (per Rao Maddipati)
DMF: >50 mg/mL (per Rao Maddipati)
DMSO: >50 mg/mL (per Rao Maddipati)
PBS (pH 7.2): >1 mg/mL (from 13(S)-HODE)
You can also refer to dose conversion for different animals. More
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20-hydroxy Leukotriene B4 79516-82-8 20-hydroxy Leukotriene B-4 20hydroxy Leukotriene B4 20 hydroxy Leukotriene B4 inhibitor inhibit