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Bucindolol

Name: Bucindolol
Brand: TargetMol
SKU: T10631
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10631Cas No. 71119-11-4

Alias MJ 131051, MJ 13105, BMY 13105

Bucindolol (BMY 13105) is a novel and potent β1-adrenergic receptor blocker that mediates vasodilation and can be used to study chronic heart failure.

Bucindolol

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Purity: 99.9%

Catalog No. T10631Alias MJ 131051, MJ 13105, BMY 13105Cas No. 71119-11-4

Bucindolol (BMY 13105) is a novel and potent β1-adrenergic receptor blocker that mediates vasodilation and can be used to study chronic heart failure.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.9%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bucindolol AI Summary

Bucindolol exhibits a wide range of bioactivities across various biological systems. It acts as a beta-adrenergic receptor blocker in normotensive rats, achieving 71.0% inhibition at 2 mg/kg, and demonstrates intrinsic sympathomimetic activity with 77.0 beats per minute in reserpinized rats. Additionally, it shows antihypertensive effects in spontaneously hypertensive rats with a 45.0 mmHg reduction in blood pressure following peroral administration and possesses vasodilator activity in ganglion-blocked rats, leading to a 26.0% decrease in mean arterial blood pressure at 3 mg/kg intravenously. Bucindolol is a potent inhibitor of the enzyme Cytochrome P450 2D6 (CYP2D6), with an IC50 value of 50.0 nM after 45 minutes of incubation. It also significantly inhibits the uptake of 4-(4-(dimethylamino)styryl)-N-methylpyridinium via human OCT1 in HEK293 cells, with an IC50 of 27,200.0 nM and 84.6% inhibition at a concentration of 100 µM. The compound shows diverse bioactivity in various other assays, including inhibition of the Menin-MLL interaction in MLL-related leukemias, GCN5L2 inhibition, delayed death inhibition of the malarial parasite plastid, and Schwann cell viability assays. Additionally, it induces DNA re-replication in SW480 colon adenocarcinoma cells, inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1), blocks viral entries, including Lassa Virus, Marburg Virus, Ebola Virus, and SARS-CoV-2, with an IC50 ranging from 16,982.44 nM to 17,000.0 nM for SARS-CoV-2. The compound also inhibits insulin secretion from INS-1E cells at different glucose concentrations, with varying potencies in the nanomolar and micromolar ranges. Lastly, Bucindolol exhibits antiviral activity against SARS-CoV-2 in VERO-E6 cells, demonstrating an IC50 range of 16,982.44 nM to 17,000.0 nM and a CC50 value of 30,900.0 nM, indicating both its potency and certain cytotoxicity to VERO-E6 cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bucindolol (BMY 13105) is a novel and potent β1-adrenergic receptor blocker that mediates vasodilation and can be used to study chronic heart failure.
Synonyms	MJ 131051, MJ 13105, BMY 13105

Chemical Properties

Molecular Weight	363.45
Formula	C₂₂H₂₅N₃O₂
Cas No.	71119-11-4
Smiles	CC(C)(Cc1c[nH]c2ccccc12)NCC(O)COc1ccccc1C#N
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (220.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7514 mL	13.7571 mL	27.5141 mL	137.5705 mL
5 mM	0.5503 mL	2.7514 mL	5.5028 mL	27.5141 mL
10 mM	0.2751 mL	1.3757 mL	2.7514 mL	13.7571 mL
20 mM	0.1376 mL	0.6879 mL	1.3757 mL	6.8785 mL
50 mM	0.0550 mL	0.2751 mL	0.5503 mL	2.7514 mL
100 mM	0.0275 mL	0.1376 mL	0.2751 mL	1.3757 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc