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Palatrigine

Name: Palatrigine
Brand: TargetMol
SKU: T24588
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24588Cas No. 98410-36-7

Alias BW-A 256C, BW A256C

Palatrigine (BW-A 256C) is a compound with angiotensin-converting enzyme inhibitory and beta-adrenergic receptor blocking properties.

Palatrigine

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Purity: 98.87%

Catalog No. T24588Alias BW-A 256C, BW A256CCas No. 98410-36-7

Palatrigine (BW-A 256C) is a compound with angiotensin-converting enzyme inhibitory and beta-adrenergic receptor blocking properties.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$80	In Stock	In Stock
5 mg	$180	In Stock	In Stock
10 mg	$260	In Stock	In Stock
25 mg	$506	In Stock	In Stock
50 mg	$680	In Stock	In Stock
100 mg	$968	In Stock	In Stock
500 mg	$1,930	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.87%

Appearance:Solid

Color:Yellow

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	Palatrigine (BW-A 256C) is a compound with angiotensin-converting enzyme inhibitory and beta-adrenergic receptor blocking properties.
In vitro	BW A256C reduced the maximum rate of depolarization of guinea-pig ventricle and dog Purkinje fibres in vitro (EC50, 2.2 X 10(-6) M and 1.8 X 10(-6) M, respectively).[1]
In vivo	In conscious dogs, BW A256C (1.5 mg/kg; intravenous infusion) or BW A256C (1.25-5 mg/kg;oral administration) caused dose-dependent suppression of the ventricular ectopic activity that occurred following 20-24 h of permanent coronary artery ligation.[1]
Synonyms	BW-A 256C, BW A256C

Chemical Properties

Molecular Weight	298.17
Formula	C₁₂H₁₃Cl₂N₅
Cas No.	98410-36-7
Smiles	NC=1C(=NN(C(C)C)C(=N)N1)C2=C(Cl)C(Cl)=CC=C2
Relative Density.	1.49g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (83.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3538 mL	16.7690 mL	33.5379 mL	167.6896 mL
5 mM	0.6708 mL	3.3538 mL	6.7076 mL	33.5379 mL
10 mM	0.3354 mL	1.6769 mL	3.3538 mL	16.7690 mL
20 mM	0.1677 mL	0.8384 mL	1.6769 mL	8.3845 mL
50 mM	0.0671 mL	0.3354 mL	0.6708 mL	3.3538 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc