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HMBPP lithium

Name: HMBPP lithium
Brand: TargetMol
SKU: TN11183
Rating: 4.5 (1 reviews)

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Catalog No. TN11183Cas No. 396726-03-7

Alias (E)-4-Hydroxy-3-methyl-but-2-enyl diphosphate lithium

HMBPP lithium is an intermediate in isoprene biosynthesis, produced by bacteria and protozoa using the non-mevalonate pathway. It serves as a ligand for the inner domain of BTN3A1 and acts as an activator of human Vγ9/Vδ2T cells. Additionally, HMBPP lithium stimulates feeding behavior in mosquitoes.

HMBPP lithium

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Catalog No. TN11183Alias (E)-4-Hydroxy-3-methyl-but-2-enyl diphosphate lithiumCas No. 396726-03-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	HMBPP lithium is an intermediate in isoprene biosynthesis, produced by bacteria and protozoa using the non-mevalonate pathway. It serves as a ligand for the inner domain of BTN3A1 and acts as an activator of human Vγ9/Vδ2T cells. Additionally, HMBPP lithium stimulates feeding behavior in mosquitoes.
In vitro	HMBPP (10 μM) lithium can stimulate feeding behavior in primary mosquito vectors when supplemented with HMBPP-enriched red blood cells. Additionally, HMBPP (10 μM, 12 hours) lithium activates purified human γδ T cells and enhances the production of CD69, intracellular perforin, IFN-γ, and TNF-α when incubated with γδ T cells and GBM cells (U251, U373, and primary GBM cultures).
In vivo	HMBPP (50 mg/kg, intramuscular injection) combined with IL-2 (subcutaneous injection, 1 million units, once daily for 5 days) induces the sustained accumulation of Vγ2Vδ2 T effector cells in the lungs of cynomolgus monkeys during inhalational Yersinia pestis infection.
Synonyms	(E)-4-Hydroxy-3-methyl-but-2-enyl diphosphate lithium

Chemical Properties

Molecular Weight	262.09
Formula	C₅H₁₂O₈P₂
Cas No.	396726-03-7
Smiles	P(OC/C=C(/CO)\C)(OP(=O)(O)O)(=O)O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc