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Arecoline

Name: Arecoline
Brand: TargetMol
SKU: T68953
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68953Cas No. 63-75-2

Arecoline is a natural alkaloid derived from areca nut in the palm family and is a potent nicotine and partial agonist of muscarinic acetylcholine receptors. Arecoline has anti-anxiety and anti-parasitic activity, can induce oxidative stress and can be used to study Alzheimer's disease and Alzheimer's disease.

Arecoline

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Purity: 99.28%

Catalog No. T68953Cas No. 63-75-2

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$40	-	In Stock
500 mg	$92	In Stock	In Stock
1 g	$133	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.28%

Appearance:Liquid

Color:Transparent to Orange

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description

In vitro

Arecoline induces reactive oxygen species generation and cell cycle arrest at the G1/G0 phase in HaCaT cells without affecting p21/Cip1 expression. It also upregulates stress-responsive genes such as hemeoxygenase-1, ferritin light chain, glucose-6-phosphate dehydrogenase, glutamate-cysteine ligase catalytic subunit, and glutathione reductase. At higher concentrations, arecoline causes epithelial cell death due to oxidative trauma without triggering apoptosis[1].

Chemical Properties

Molecular Weight	155.19
Formula	C₈H₁₃NO₂
Cas No.	63-75-2
Smiles	C(OC)(=O)C=1CN(C)CCC1

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (354.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.4437 mL	32.2186 mL	64.4371 mL	322.1857 mL
5 mM	1.2887 mL	6.4437 mL	12.8874 mL	64.4371 mL
10 mM	0.6444 mL	3.2219 mL	6.4437 mL	32.2186 mL
20 mM	0.3222 mL	1.6109 mL	3.2219 mL	16.1093 mL
50 mM	0.1289 mL	0.6444 mL	1.2887 mL	6.4437 mL
100 mM	0.0644 mL	0.3222 mL	0.6444 mL	3.2219 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc