Renin FRET Substrate I

Name: Renin FRET Substrate I
Brand: TargetMol
SKU: T38900
Rating: 4.5 (1 reviews)

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Catalog No. T38900Cas No. 142988-22-5

Renin FRET Substrate I is a specific compound designed to function as a substrate for human renin, containing the exact cleavage site found in the N-terminal peptide of human angiotensinogen.

Renin FRET Substrate I

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Catalog No. T38900Cas No. 142988-22-5

Renin FRET Substrate I is a specific compound designed to function as a substrate for human renin, containing the exact cleavage site found in the N-terminal peptide of human angiotensinogen.

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Product Introduction

Bioactivity

Description	Renin FRET Substrate I is a specific compound designed to function as a substrate for human renin, containing the exact cleavage site found in the N-terminal peptide of human angiotensinogen.
In vitro	The chemical compound specifically cleaves the Renin FRET Substrate I at the Leu-Val bond, mirroring the renin cleavage site on angiotensinogen[1].

Chemical Properties

Molecular Weight	1798.15
Formula	C₉₀H₁₂₀N₂₂O₁₆S
Cas No.	142988-22-5
Smiles	CC[C@H](C)[C@H](NC(=O)CCCNC(=O)c1ccc(cc1)N=Nc1ccc(cc1)N(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCNc1cccc2c(cccc12)S(O)(=O)=O \|w:20.20,@@:81\|
Relative Density.	1.38 g/cm3 (Predicted)
Sequence	DABCYL-γ-{Abu}-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Glu-Asp-Ala-Asn-Ser
Sequence Short	DABCYL-γ-{Abu}-IHPFHLVIHT-EDANS

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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