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Casimersen
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Catalog No. T38859Cas No. 1422958-19-7
Alias SRP-4045, SRP4045, SRP 4045
Casimersen (SRP-4045) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer class that binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame through exon 45 skipping. Casimersen enables the production of an internally truncated yet functional dystrophin protein, thereby serving as a specialized molecular tool for studying exon-skipping mechanisms and therapeutic development in Duchenne muscular dystrophy research.
Casimersen
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Catalog No. T38859Alias SRP-4045, SRP4045, SRP 4045Cas No. 1422958-19-7
Casimersen (SRP-4045) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer class that binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame through exon 45 skipping. Casimersen enables the production of an internally truncated yet functional dystrophin protein, thereby serving as a specialized molecular tool for studying exon-skipping mechanisms and therapeutic development in Duchenne muscular dystrophy research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $315 | 2-4 weeks | 2-4 weeks | |
| 5 mg | $629 | 2-4 weeks | 2-4 weeks | |
| 10 mg | $978 | 2-4 weeks | 2-4 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Casimersen (SRP-4045) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer class that binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame through exon 45 skipping. Casimersen enables the production of an internally truncated yet functional dystrophin protein, thereby serving as a specialized molecular tool for studying exon-skipping mechanisms and therapeutic development in Duchenne muscular dystrophy research. |
| In vitro | Exon 45 skipping aims to facilitate the production of a shorter, internally truncated form of dystrophin protein in patients whose genetic mutations make them suitable candidates for Exon 45 skipping[2]. |
| Synonyms | SRP-4045, SRP4045, SRP 4045 |
| Cas No. | 1422958-19-7 |
| Relative Density. | no data available |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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