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Dynorphin A

Name: Dynorphin A
Brand: TargetMol
SKU: TP2040
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP2040Cas No. 80448-90-4

Dynorphin A is an endogenous opioid peptide and a κ-opioid receptor (KOR) agonist, with some agonistic activity on μ- and δ-opioid receptors. It primarily functions as a neurotransmitter and regulator in the central and peripheral nervous systems, exerting analgesic and mood-regulating effects.

Dynorphin A

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Purity: 95.93%

Catalog No. TP2040Cas No. 80448-90-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$61	-	In Stock
5 mg	$223	-	In Stock
10 mg	$304	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:95.93%

Appearance:Solid

Color:White

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COA MS HPLC

Product Introduction

Bioactivity

Description	Dynorphin A is an endogenous opioid peptide and a κ-opioid receptor (KOR) agonist, with some agonistic activity on μ- and δ-opioid receptors. It primarily functions as a neurotransmitter and regulator in the central and peripheral nervous systems, exerting analgesic and mood-regulating effects.
In vitro	Method: Mouse striatal neurons were treated with Dynorphin A at a concentration of 10 μM, and cell viability was assessed at 0, 24, 48, and 72 hours to evaluate its effect on neuronal survival. Result: Dynorphin A treatment induced neuronal death, characterized by fragmentation and destruction of the cell body and neurites. [3]
In vivo	Method: A 24-hour water-deprived male rat model was used, and Dynorphin A (1 μg in 2 μL) was administered via intracerebroventricular injection to evaluate its effect on vasopressin (VP) release. Result: Dynorphin A inhibited vasopressin release within 30 minutes after injection. [5]

Chemical Properties

Molecular Weight	2147.48
Formula	C₉₉H₁₅₅N₃₁O₂₃
Cas No.	80448-90-4
Smiles	C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC(CNC(CNC([C@H](CC3=CC=C(O)C=C3)N)=O)=O)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)CCC1)CCCCN)=O)CC(C)C)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)CC(N)=O)=O)CC(O)=O)=O)C=4C=5C(NC4)=CC=CC5
Relative Density.	1.46 g/cm3 (Predicted)
Sequence	Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln
Sequence Short	YGGFLRRIRPKLKWDNQ

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (37.25 mM), Sonication is recommended.

DMSO: 80 mg/mL (37.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (1.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.4657 mL	2.3283 mL	4.6566 mL	23.2831 mL
5 mM	0.0931 mL	0.4657 mL	0.9313 mL	4.6566 mL
10 mM	0.0466 mL	0.2328 mL	0.4657 mL	2.3283 mL
20 mM	0.0233 mL	0.1164 mL	0.2328 mL	1.1642 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc