Shopping Cart

Your shopping cart is currently empty

Dynorphin A

Name: Dynorphin A
Brand: TargetMol
SKU: TP2040
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TP2040Cas No. 80448-90-4

Dynorphin A is an endogenous opioid peptide and a κ-opioid receptor (KOR) agonist, with some agonistic activity on μ- and δ-opioid receptors. It primarily functions as a neurotransmitter and regulator in the central and peripheral nervous systems, exerting analgesic and mood-regulating effects.

Dynorphin A

🥰Excellent

Purity: 95.93%

Catalog No. TP2040Cas No. 80448-90-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$61	-	In Stock
5 mg	$223	-	In Stock
10 mg	$304	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:95.93%

Resource Download

COA MS HPLC

Product Introduction

Bioactivity

Description	Dynorphin A is an endogenous opioid peptide and a κ-opioid receptor (KOR) agonist, with some agonistic activity on μ- and δ-opioid receptors. It primarily functions as a neurotransmitter and regulator in the central and peripheral nervous systems, exerting analgesic and mood-regulating effects.
In vitro	Method: Mouse striatal neurons were treated with Dynorphin A at a concentration of 10 μM, and cell viability was assessed at 0, 24, 48, and 72 hours to evaluate its effect on neuronal survival. Result: Dynorphin A treatment induced neuronal death, characterized by fragmentation and destruction of the cell body and neurites. [3]
In vivo	Method: A 24-hour water-deprived male rat model was used, and Dynorphin A (1 μg in 2 μL) was administered via intracerebroventricular injection to evaluate its effect on vasopressin (VP) release. Result: Dynorphin A inhibited vasopressin release within 30 minutes after injection. [5]

Chemical Properties

Molecular Weight	2147.48
Formula	C₉₉H₁₅₅N₃₁O₂₃
Cas No.	80448-90-4
Smiles	C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC(CNC(CNC([C@H](CC3=CC=C(O)C=C3)N)=O)=O)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)CCC1)CCCCN)=O)CC(C)C)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)CC(N)=O)=O)CC(O)=O)=O)C=4C=5C(NC4)=CC=CC5
Relative Density.	1.46 g/cm3 (Predicted)
Sequence	Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln
Sequence Short	YGGFLRRIRPKLKWDNQ

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (37.25 mM), Sonication is recommended.

DMSO: 80 mg/mL (37.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (1.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.4657 mL	2.3283 mL	4.6566 mL	23.2831 mL
5 mM	0.0931 mL	0.4657 mL	0.9313 mL	4.6566 mL
10 mM	0.0466 mL	0.2328 mL	0.4657 mL	2.3283 mL
20 mM	0.0233 mL	0.1164 mL	0.2328 mL	1.1642 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc