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Dynorphin A

Name: Dynorphin A
Brand: TargetMol
SKU: TP2040
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TP2040Cas No. 80448-90-4

Dynorphin A is an endogenous opioid peptide and a κ-opioid receptor (KOR) agonist, with some agonistic activity on μ- and δ-opioid receptors. It primarily functions as a neurotransmitter and regulator in the central and peripheral nervous systems, exerting analgesic and mood-regulating effects.

Dynorphin A

🥰Excellent

Purity: 95.93%

Catalog No. TP2040Cas No. 80448-90-4

Pack Size	Price	Availability
1 mg	$61	In Stock
5 mg	$223	In Stock
10 mg	$304	In Stock

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Batch Information

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Purity:95.93%

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COA MS HPLC

Product Introduction

Bioactivity

Description	Dynorphin A is an endogenous opioid peptide and a κ-opioid receptor (KOR) agonist, with some agonistic activity on μ- and δ-opioid receptors. It primarily functions as a neurotransmitter and regulator in the central and peripheral nervous systems, exerting analgesic and mood-regulating effects.
In vitro	Method: Mouse striatal neurons were treated with Dynorphin A at a concentration of 10 μM, and cell viability was assessed at 0, 24, 48, and 72 hours to evaluate its effect on neuronal survival. Result: Dynorphin A treatment induced neuronal death, characterized by fragmentation and destruction of the cell body and neurites. [3]
In vivo	Method: A 24-hour water-deprived male rat model was used, and Dynorphin A (1 μg in 2 μL) was administered via intracerebroventricular injection to evaluate its effect on vasopressin (VP) release. Result: Dynorphin A inhibited vasopressin release within 30 minutes after injection. [5]

Chemical Properties

Molecular Weight	2147.48
Formula	C₉₉H₁₅₅N₃₁O₂₃
Cas No.	80448-90-4
Smiles	C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC(CNC(CNC([C@H](CC3=CC=C(O)C=C3)N)=O)=O)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)CCC1)CCCCN)=O)CC(C)C)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)CC(N)=O)=O)CC(O)=O)=O)C=4C=5C(NC4)=CC=CC5
Relative Density.	1.46 g/cm3 (Predicted)
Sequence	Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln
Sequence Short	YGGFLRRIRPKLKWDNQ

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (37.25 mM), Sonication is recommended.

DMSO: 80 mg/mL (37.25 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.4657 mL	2.3283 mL	4.6566 mL	23.2831 mL
5 mM	0.0931 mL	0.4657 mL	0.9313 mL	4.6566 mL
10 mM	0.0466 mL	0.2328 mL	0.4657 mL	2.3283 mL
20 mM	0.0233 mL	0.1164 mL	0.2328 mL	1.1642 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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